Kasper, Michael <br/><br/>
The Alveolar Epithelium : Mechanisms of Injury and Repair 

 - Basel, Switzerland  MDPI - Multidisciplinary Digital Publishing Institute  2020 
 - 1 electronic resource (222 p.) 
<br/><br/> Open Access 
<br/><br/> Alveolar epithelial cells (AECs) of the lung are important contributors to pulmonary immune functions and to pulmonary development and alveolar repair mechanisms following lung injury. AECI, together with the capillary endothelium, form the extremely thin barrier between alveolar air and blood. AECII produce and metabolize the surface-tension lowering and immune-modulating surfactant and are the progentiors of AECI. A great variety of processes rely on their normal functioning, including maintenance of the alveolar barrier; innate immune defense; and processes of differentiation, senescence, apoptosis, and autophagy. The wide range of AEC functions is nicely reflected by the diversity of topics addressed by the four review and eight original articles contained in this Special Issue of the International Journal of Molecular Sciences. Beyond the broad spectrum of topics, the authors of this issue also made use of an impressive variety of analytical methods, thus further illustrating the fascinating diversity of aspects related to AEC biology. 
<br/><br/><br/>Creative Commons 
<br/><br/><br/>English 
<br/><br/><label>ISBN: </label>books978-3-03943-167-0 9783039431663 9783039431670 
<br/><br/><label>Standard No.: </label>10.3390/books978-3-03943-167-0  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Research & information: general<br/>Biology, life sciences
<br/><br/><label>Subjects--Index Terms: </label>JAM-A P2X7 receptor mouse lung alveolar epithelium bleomycin-induced lung injury GSK-3β dietary sugar hyperglycemia lung mechanics alveolar septal composition physical activity extracellular matrix remodeling high-altitude pulmonary edema acute mountain sickness oxygen diffusion limitation surfactant protein B atelectrauma alveolar fluid acinar micromechanics acute lung injury autophagy lysosome lysosomal membrane permeability mitochondria pneumocyte microRNA-21 alveolar micromechanics structural remodeling inflammatory signaling lung alveolus type 1 alveolar epithelial cell type 2 alveolar epithelial cell focused ion beam scanning electron microscopy 3D reconstruction carbon dioxide hypercapnia Na,K-ATPase endoplasmic reticulum sodium transport protein oxidation alveolar epithelial cells pulmonary fibrosis epithelial cell dysfunction stem cell exhaustion pneumonia necrotizing regeneration model bovine chlamydia alveoli air-blood barrier epithelium air-liquid interface alveolar lining layer glycocalyx surfactant lung injury lung regeneration