TY - GEN AU - Reinhard Dallinger (Ed) TI - Metal Metabolism in Animals SN - 9783038428442 PY - 2018/// PB - MDPI - Multidisciplinary Digital Publishing Institute KW - Allergy KW - Protein Biochemistry KW - Oxidative Stress KW - Metalloprotein KW - Homeostasis KW - Metal Uptake KW - Iron KW - Metal KW - Synthase KW - Immunity KW - Accumulation KW - Model Organism KW - Methylmercury KW - Development KW - Metal Toxicity KW - Essential Trace Element KW - Copper KW - Protection KW - Molecular Methods KW - Metal Supplementation KW - Binding Specificity KW - Cadmium KW - Transgenic Organisms KW - T Cells KW - Non-Essential Trace Element KW - Animal Model KW - Hypersensitivity KW - Detoxification KW - Tolerance KW - Histology KW - Palladium KW - Metalloenzyme KW - Stress KW - Zinc KW - Regulation KW - Nickel KW - Protein Disease KW - Mercury KW - Phytochelatin KW - Metallothionein KW - Apoptosis KW - Cancer N1 - Open Access N2 - Through evolution of life, animals have adapted to the ubiquitous presence of metals in the biosphere. They utilize the more frequent ones as essential constituents of their biochemical machinery. In fact, about 40% of all proteins present in animal cells are so-called metalloproteins. On the other hand, animals have invented regulatory and detoxifying mechanisms to protect themselves from critical concentrations of both essential and non-essential metal concentrations. Metallomics is a modern approach applying cellular, biochemical, molecular and analytical methods to investigate the relationships of metals in their cellular context. The present edition contains a number of original articles and reviews dealing with various aspects of metallomics in animals, published as Special Issues of the International Journal of Molecular Sciences in 2016 and 2017. The book addresses subjects such as metal definition in biology, metabolism of metals in invertebrate and vertebrate animals, metal detoxification and regulation strategies, supplementation of essential trace elements, metal behavior in pregnancy and embryonic development, as well as metal toxicology and emerging medical implications UR - http://www.mdpi.com/books/pdfview/book/588 UR - https://directory.doabooks.org/handle/20.500.12854/53247 ER -