TY  - GEN
AU  - Lopez-Contreras,Andres Joaquin
AU  - Fernandez-Capetillo,Oscar
AU  - Joaquin,Andres
AU  - Fernandez-Capetillo,Oscar
TI  - Chapter 8 Signalling DNA Damage
SN  - 50863
PY  - 2012///
PB  - InTechOpen
KW  - Science: general issues
KW  - bicssc
KW  - dna damage
KW  - Apoptosis
KW  - Ataxia telangiectasia and Rad3 related
KW  - ATM serine/threonine kinase
KW  - DNA repair
KW  - DNA-PKcs
KW  - Phosphorylation
KW  - Protein
KW  - Ubiquitin
N1  - Open Access
N2  - During our lifetime, the genome is constantly being exposed to different types of damage caused either by exogenous sources (radiations and/or genotoxic compound) but also as byproducts of endogenous processes (reactive oxigen species during respiration, stalled forks during replication, eroded telomeres, etc). From a structural point of view, there are many types of DNA damage including single or double strand breaks, base modifications and losses or base-pair mismatches. The amount of lesions that we face is enormous with estimates suggesting that each of our 1013 cells has to deal with around 10.000 lesions per day [1]. While the majority of these events are properly resolved by specialized mechanisms, a deficient response to DNA damage, and particularly to DSB, harbors a serious threat to human health [2].    DSB can be formed [1] following an exposure to ionizing radiation (X- or γ-rays) or clastogenic drugs; [2] endogenously, during DNA replication, or [3], as a consequence of reactive oxygen species (ROS) generated during oxidative metabolism. In addition, programmed DSB are used as repair intermediates during V(D)J and Class-Switch recombination (CSR) in lymphocytes [3], or during meiotic recombination [4]. Because of this, immunodeficiency and/or sterility problems are frequently associated with DDR-related pathologies
UR  - https://library.oapen.org/bitstream/20.500.12657/32323/1/612634.pdf
UR  - https://library.oapen.org/bitstream/20.500.12657/32323/1/612634.pdf
UR  - https://library.oapen.org/bitstream/20.500.12657/32323/1/612634.pdf
UR  - https://directory.doabooks.org/handle/20.500.12854/33854
ER  -