David J. Nikolic-Paterson <br/><br/>
Advances in Mechanisms of Renal Fibrosis 

 -  Frontiers Media SA  2018 
 - 1 electronic resource (84 p.) 
<br/><br/> Open Access 
<br/><br/> Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis. 
<br/><br/><br/>Creative Commons 
<br/><br/><br/>English 
<br/><br/><label>ISBN: </label>978-2-88945-499-0 9782889454990 
<br/><br/><label>Standard No.: </label>10.3389/978-2-88945-499-0  doi 
<br/><br/><label>Subjects--Index Terms: </label>TGF-beta fibroblast JNK miRNA Smad non-classical RAS BMP7 HDAC HIPK2