TY  - GEN
AU  - David J.Nikolic-Paterson
AU  - Hui Y.Lan
TI  - Advances in Mechanisms of Renal Fibrosis
SN  - 978-2-88945-499-0
PY  - 2018///
PB  - Frontiers Media SA
KW  - TGF-beta
KW  - fibroblast
KW  - JNK
KW  - miRNA
KW  - Smad
KW  - non-classical RAS
KW  - BMP7
KW  - HDAC
KW  - HIPK2
N1  - Open Access
N2  - Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis
UR  - https://www.frontiersin.org/research-topics/3106/advances-in-mechanisms-of-renal-fibrosis
UR  - https://directory.doabooks.org/handle/20.500.12854/40307
ER  -