TY  - GEN
AU  - Magdalena Plebanski
AU  - Eric J.Gowans
AU  - Peter Smooker
AU  - Shuo Li
TI  - Why vaccines to HIV, HCV and Malaria have so far failed - Challenges to developing vaccines against immunoregulating pathogens
SN  - 978-2-88919-966-2
PY  - 2016///
PB  - Frontiers Media SA
KW  - influenza
KW  - HIV
KW  - Malaria
KW  - Infectious Disease
KW  - Genetics
KW  - Vaccine
KW  - HCV
KW  - immunology
N1  - Open Access
N2  - Despite continuous progress in the development of anti-viral and anti-bacterial/parasite drugs, the high cost of medicines and the potential for re-infection, especially in high risk groups, suggest that protective vaccines to some of the most dangerous persistent infections are still highly desirable. There are no vaccines available for HIV, HCV and Malaria, and all attempts to make a broadly effective vaccine have failed so far. In this Research Topic we look into why vaccines have failed over the years, and what we have learn from these attempts. Rather than only showing positive results, this issue aims to reflect on failed efforts in vaccine development. Coming to understand our limitations will have theoretical and practical implications for the future development of vaccines to these major global disease burdens
UR  - http://journal.frontiersin.org/researchtopic/2072/why-vaccines-to-hiv-hcv-and-malaria-have-so-far-failed---challenges-to-developing-vaccines-against-i
UR  - https://directory.doabooks.org/handle/20.500.12854/62680
ER  -