TY  - GEN
AU  - Tania L.Roth
AU  - Karestan C.Koenen
AU  - David M.Diamond
TI  - Epigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome
SN  - 978-2-88919-458-2
PY  - 2015///
PB  - Frontiers Media SA
KW  - PTSD
KW  - stress
KW  - Fear
KW  - DNA Methylation
KW  - Histones
KW  - miRNA
N1  - Open Access
N2  - This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry
UR  - http://journal.frontiersin.org/researchtopic/966/epigenetic-pathways-in-ptsd-how-traumatic-experiences-leave-their-signature-on-the-genome
UR  - https://directory.doabooks.org/handle/20.500.12854/46667
ER  -