TY  - GEN
AU  - Dansette,Patrick M.
AU  - Werck,Danièle
AU  - Dansette,Patrick M.
AU  - Werck,Danièle
TI  - Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0
SN  - books978-3-0365-0257-1
PY  - 2021///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Research & information: general
KW  - bicssc
KW  - Antibiotics
KW  - Bacillus
KW  - biosynthetic gene clusters
KW  - comparative analysis
KW  - cytochrome P450 monooxygenase
KW  - Mycobacterium
KW  - P450 diversity percentage
KW  - P450 profiling
KW  - secondary metabolites
KW  - NADPH-cytochrome P450 reductase (CPR)
KW  - microsomal cytochrome P450 (CYP)
KW  - Cytochrome b5 (CYB5)
KW  - protein dynamics
KW  - electron-transfer (ET)
KW  - protein–protein interaction
KW  - cytochromes P450
KW  - CYP3A4
KW  - active site access channels
KW  - cavities boundaries
KW  - minimal cost paths
KW  - CYP139A1
KW  - genome data mining
KW  - host metabolism
KW  - Mycobacterium tuberculosis
KW  - polyketides
KW  - tuberculosis
KW  - cryptococcus
KW  - cryptococcus neoformans
KW  - CYP51
KW  - fungal pathogens
KW  - genome data-mining
KW  - human pathogens
KW  - CYP diversity analysis
KW  - tremellomycetes
KW  - trichosporon
KW  - mechanism-based inhibitor
KW  - crystal structure
KW  - CYP4 genes
KW  - genetic polymorphisms
KW  - 20-HETE
KW  - fatty acid
KW  - arachidonic acid
KW  - SNPs
KW  - molecular functionality
KW  - metabolism
KW  - lamellar ichthyosis
KW  - Bietti’s crystalline dystrophy
KW  - cytochrome P450
KW  - isoform
KW  - membrane protein
KW  - protein-membrane interactions
KW  - enzyme substrate specificity
KW  - mutagenesis
KW  - molecular dynamics simulation
KW  - Sogatella furcifera
KW  - sulfoxaflor
KW  - transcriptome
KW  - RNA interference
KW  - CYP2C8
KW  - polymorphisms
KW  - reactive oxygen species
KW  - paclitaxel
KW  - cytochrome P450 reductase
KW  - electron transfer
KW  - extracellular vesicles
KW  - exosomes
KW  - extrahepatic tissues
KW  - plasma
KW  - circulatory CYPs
KW  - CYP450
KW  - drug metabolism
KW  - precision Cardio-Oncology
KW  - precision medicine
KW  - systems medicine
KW  - cytochromes P450 monooxygenases
KW  - Cyanobacteria
KW  - gene-cluster diversity percentage
KW  - mathematical formula
KW  - phylogenetic analysis
KW  - Streptomyces
KW  - cytochrome P450 monooxygenases
KW  - terpenes
KW  - P450 blooming
KW  - non-ribosomal peptides
KW  - cytochrome P450 monooxygenenases
KW  - CYP128A1
KW  - Mycobacterium tuberculosis H37Rv
KW  - molecular dynamic simulations
KW  - azole drugs
KW  - menaquinone
N1  - Open Access
N2  - This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects.  The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase.  Then, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers.  Five papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis.  The subject of the last paper is CYP in Sogatella furcifera, a plant pest, and its resistance to the insecticide sulfoxaflor
UR  - https://mdpi.com/books/pdfview/book/3958
UR  - https://directory.doabooks.org/handle/20.500.12854/76512
ER  -