Kipp, Markus <br/><br/>
Oligodendrocyte Physiology and Pathology Function 

 - Basel, Switzerland  MDPI - Multidisciplinary Digital Publishing Institute  2021 
 - 1 electronic resource (330 p.) 
<br/><br/> Open Access 
<br/><br/> The adult vertebrate central nervous system mainly consists of neurons, astrocytes, microglia cells, and oligodendrocytes. Oligodendrocytes, the myelin-forming cells of the CNS, are subjected to cell stress and subsequent death in a number of metabolic or inflammatory disorders, among which multiple sclerosis (MS) is included. This disease is associated with the development of large demyelinated plaques, oligodendrocyte destruction, and axonal degeneration, paralleled by the activation of astrocytes and microglia as well as the recruitment of peripheral immune cells to the site of tissue injury. Of note, viable oligodendrocytes and an intact myelin sheath are indispensable for neuronal health. For example, it has been shown that oligodendrocytes provide nutritional support to neurons, fast axonal transport depends on proper oligodendrocyte function, and mice deficient in mature myelin proteins eventually display severe neurodegeneration. This Special Issue contains a collection of highly relevant primary research articles as well as review articles focusing on the development, physiology, and pathology of the oligodendrocyte–axon–myelin unit. 
<br/><br/><br/>Creative Commons 
<br/><br/><br/>English 
<br/><br/><label>ISBN: </label>books978-3-03943-690-3 9783039436897 9783039436903 
<br/><br/><label>Standard No.: </label>10.3390/books978-3-03943-690-3  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Medicine<br/>Neurosciences
<br/><br/><label>Subjects--Index Terms: </label>plasma membrane proteins liquid chromatography-mass spectrometry murine acute brain slices reproducibility rat cerebellum Nsun5 Williams-Beuren syndrome (WBS) corpus callosum (CC) oligodendrocyte (OL) myelination remyelination EGFR inhibitor smoothened agonist microfibers drug screening multiple sclerosis cuprizone atrophy design-based stereology 18F-FDG macromolecular proton fraction MPF myelin magnetic resonance imaging cuprizone model demyelination oligodendrocyte precursors oligodendrocytes immunohistochemistry oligodendrocyte epigenetics neurodegeneration laquinimod energy drinks caffeine taurine neuron OPC oligodendrocyte progenitor cells screening nanofibers DigiGait™ experimental autoimmune encephalomyelitis gait analysis schizophrenia interneuron pluripotent stem cells cognition treatment cre-recombinase experimental autoimmune encephalomyelitis (EAE) glial progenitor cells tamoxifen down syndrome white matter glial fate transient receptor potential ankyrin 1 astrocyte conditional knockout astrocytes white matter disease cross-talk CNS glial cells. age microglia n/a