TY  - GEN
AU  - Murray-Stewart,Tracy
TI  - Polyamine Metabolism in Disease and Polyamine-Targeted Therapies
SN  - books978-3-03921-153-1
PY  - 2019///
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - protein synthesis in cancer
KW  - neuroblastoma
KW  - epigenetics
KW  - Drosophila imaginal discs
KW  - pneumococcal pneumonia
KW  - transgenic mice
KW  - spermidine/spermine N1-acetyl transferase
KW  - ?-difluoromethylornithine
KW  - MYC
KW  - skeletal muscle
KW  - protein expression
KW  - curcumin
KW  - colorectal cancer
KW  - autophagy
KW  - human embryonic kidney 293 (HEK293)
KW  - melanoma
KW  - tumor immunity
KW  - Snyder-Robinson Syndrome
KW  - Streptococcus pneumoniae
KW  - B-lymphocytes
KW  - autoimmunity
KW  - spermine oxidase
KW  - cell differentiation
KW  - diferuloylmethane
KW  - immunity
KW  - antizyme
KW  - transgenic mouse
KW  - polyamine
KW  - hirsutism
KW  - chemoprevention
KW  - CRISPR
KW  - transglutaminase
KW  - polyamine analogs
KW  - NF-?B
KW  - spermine synthase
KW  - atrophy
KW  - aging
KW  - oxidative stress
KW  - mast cells
KW  - African sleeping sickness
KW  - pancreatic ductal adenocarcinoma
KW  - eflornithine
KW  - carcinogenesis
KW  - ornithine decarboxylase
KW  - polyamine transport inhibitor
KW  - putrescine
KW  - neutrophils
KW  - spermidine
KW  - untranslated region
KW  - spermine
KW  - polyphenol
KW  - M2 macrophages
KW  - polyamine transport system
KW  - metabolism
KW  - difluoromethylorthinine
KW  - DFMO
KW  - antizyme inhibitors
KW  - capsule
KW  - polyamine transport
KW  - eosinophils
KW  - MCF-7 cells
KW  - difluoromethylornithine
KW  - polyamine metabolism
KW  - mutant BRAF
KW  - polyamines
KW  - cadaverine
KW  - proteomics
KW  - airway smooth muscle cells
KW  - breast cancer
KW  - X-linked intellectual disability
KW  - complementation
KW  - T-lymphocytes
KW  - bis(ethyl)polyamine analogs
KW  - antizyme 1
KW  - cancer
KW  - osteosarcoma
N1  - Open Access
N2  - Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis. Dysregulation of these multifaceted polyamine functions contribute to multiple disease processes, thus their metabolism and function have been targeted for preventive or therapeutic intervention. The correlation between elevated polyamine levels and cancer is well established, and ornithine decarboxylase, the rate-limiting biosynthetic enzyme in the production of putrescine, is a bona fide transcriptional target of the Myc oncogene. Furthermore, induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation through the production of reactive oxygen species. These and other characteristics specific to cancer cells have led to the development of polyamine-based agents and inhibitors aimed at exploiting the polyamine metabolic pathway for chemotherapeutic and chemopreventive benefit. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases including Alzheimer’s and Parkinson’s, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines are known to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses, as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy
UR  - https://mdpi.com/books/pdfview/book/1582
UR  - https://directory.doabooks.org/handle/20.500.12854/56626
ER  -