van Noort, Danny

Microfluidics for Cells and Other Organisms - MDPI - Multidisciplinary Digital Publishing Institute 2019 - 1 electronic resource (200 p.)

Open Access

Microfluidics-based devices play an important role in creating realistic microenvironments in which cell cultures can thrive. They can, for example, be used to monitor drug toxicity and perform medical diagnostics, and be in a static-, perfusion- or droplet-based device. They can also be used to study cell-cell, cell-matrix or cell-surface interactions. Cells can be either single cells, 3D cell cultures or co-cultures. Other organisms could include bacteria, zebra fish embryo, C. elegans, to name a few.


Creative Commons


English

books978-3-03921-563-8 9783039215638 9783039215621

10.3390/books978-3-03921-563-8 doi

n/a screening microfluidic device cell homogenous dispersion structure RNA biomedical engineering neural networks single-cell mechanics on-chip cell incubator cell growth embryogenesis cancer stem cell intracellular proteins simultaneous multiple chamber observation instrumentation fnRBC cancer metastasis Wheatstone bridge capillary single-cell manipulation adherent cells nucleic acid micropipette aspiration sample preparation unsupervised learning cell motility capture efficiency bacterial concentration cbNIPD microfabrication drug resistance variational inference microfluidics periodic hydrostatic pressure paracrine signaling periodic pressure capacitively coupled contactless conductivity detection (C4D) bioMEMS microfluidic flow cytometry particle/cell imaging co-culture cells-in-gels-in-paper laminar flows E. coli printed-circuit-board (PCB) pneumatic microvalve time-lapse observation nanostructure 3D particle focusing target cell-specific binding molecules absolute quantification DNA zebrafish embryo microscopy 3D printing 3D flow focusing single-cell analysis