Ortega, Ángel  Luis <br/><br/>
Oxidative Stress in Diabetic Retinopathy 

 - Basel, Switzerland  MDPI - Multidisciplinary Digital Publishing Institute  2021 
 - 1 electronic resource (322 p.) 
<br/><br/> Open Access 
<br/><br/> The combination of an increasing prevalence of diabetes and the aging of populations enables the appearance of a greater number of associated complications such as diabetic retinopathy. Diabetic retinopathy is the leading cause of preventable vision loss in working-age adults. The objective of this Special Issue is to highlight the existing evidence regarding the relationship between oxidative stress and low-grade chronic inflammation induced by hyperglycemia with the development and progression of diabetic retinopathy, with an emphasis on the importance of early diagnosis and the use of antioxidant and anti-inflammatory approaches to prevent or delay the harmful effects of diabetes on retinal tissue. 
<br/><br/><br/>Creative Commons 
<br/><br/><br/>English 
<br/><br/><label>ISBN: </label>books978-3-0365-0449-0 9783036504483 9783036504490 
<br/><br/><label>Standard No.: </label>10.3390/books978-3-0365-0449-0  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Medicine
<br/><br/><label>Subjects--Index Terms: </label>eicosanoids oxidative stress diabetic retinopathy cyclooxygenase lipoxygenase Cytochrome P450 HDAC6 tubastatin A retinal endothelial cells retinal endothelial cell senescence db/db mice Cinnamomi Ramulus Paeoniae Radix CPA4-1 blood-retinal barrier occludin human retina epiretinal membrane internal limiting membrane vitreoretinal surgery macular hole proliferative diabetic retinopathy antioxidants diabetes mellitus free radicals high-mobility group box 1 (HMGB1) inflammatory pathways novel therapies diabetic retinopathy (DR) inflammation angiogenesis extracellular vesicles miRNA biomarkers apoptosis fenofibrate thioredoxin hyperglycemia astaxanthin carotenoid reactive oxygen species photoreceptor cells PI3K Nrf2 eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA) retinal pigment epithelium antioxidant ascorbic acid retinal disease vitamin D GLP-1 superoxide dismutase biomarkers of diabetic retinopathy metabolic memory tear film aqueous humor vitreous humor mitochondria redox photoreceptor glycation aging glyoxalase n/a