TY  - GEN
AU  - Brust,Peter
AU  - Brust,Peter
TI  - Radiolabelled Molecules for Brain Imaging with PET and SPECT
SN  - books978-3-03936-721-4
PY  - 2020///
CY  - Basel, Switzerland
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - Research & information: general
KW  - bicssc
KW  - Biology, life sciences
KW  - SV2A
KW  - SV2B
KW  - SV2C
KW  - microPET
KW  - [18F]UCB-H
KW  - epilepsy
KW  - PBIF
KW  - distribution volume
KW  - blocking assay
KW  - preclinical imaging
KW  - Alzheimer’s disease (AD)
KW  - network measure
KW  - graph theory
KW  - brain network
KW  - positron emission tomography (PET)
KW  - persistent homology
KW  - Phosphodiesterase 2A (PDE2A)
KW  - Positron Emission Tomography (PET)
KW  - Benzoimidazotriazine (BIT)
KW  - fluorinated
KW  - Mouse Liver Microsomes (MLM)
KW  - cyclic nucleotide phosphodiesterase
KW  - PDE2A radioligand
KW  - nitro-precursor
KW  - fluorine-18
KW  - in vitro autoradiography
KW  - PET imaging
KW  - opioid receptors
KW  - positron emission tomography
KW  - radiotracers
KW  - μOR-, δOR-, κOR- and ORL1-ligands
KW  - movement disorders
KW  - pain
KW  - drug dependence
KW  - GBM
KW  - biomarkers
KW  - Sigma 1
KW  - Sigma 2
KW  - PD-L1
KW  - PARP
KW  - IDH
KW  - Alzheimer’s disease
KW  - Parkinson’s disease
KW  - β-amyloid plaques
KW  - neurofibrillary tangles
KW  - α-synucleinopathy
KW  - diagnostic imaging probes
KW  - orexin receptors
KW  - PET
KW  - radiotracer
KW  - imaging
KW  - alpha 7
KW  - nicotinic acetylcholine receptors
KW  - nAChR
KW  - autoradiography
KW  - amino acid
KW  - FET
KW  - FACBC
KW  - FDOPA
KW  - immunoPET
KW  - molecular imaging
KW  - glioma
KW  - brain metastases
KW  - adenosine A2A receptor
KW  - rotenone-based mouse model
KW  - [18F]FESCH
KW  - two-step one-pot radiosynthesis
N1  - Open Access
N2  - Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are in vivo molecular imaging methods which are widely used in nuclear medicine for diagnosis and treatment follow-up of many major diseases. These methods use target-specific molecules as probes, which are labeled with radionuclides of short half-lives that are synthesized prior to the imaging studies. These probes are called radiopharmaceuticals. The use of PET and SPECT for brain imaging is of special significance since the brain controls all the body’s functions by processing information from the whole body and the outside world. It is the source of thoughts, intelligence, memory, speech, creativity, emotion, sensory functions, motion control, and other important body functions. Protected by the skull and the blood–brain barrier, the brain is somehow a privileged organ with regard to nutrient supply, immune response, and accessibility for diagnostic and therapeutic measures. Invasive procedures are rather limited for the latter purposes. Therefore, noninvasive imaging with PET and SPECT has gained high importance for a great variety of brain diseases, including neurodegenerative diseases, motor dysfunctions, stroke, epilepsy, psychiatric diseases, and brain tumors. This Special Issue focuses on radiolabeled molecules that are used for these purposes, with special emphasis on neurodegenerative diseases and brain tumors
UR  - https://mdpi.com/books/pdfview/book/3140
UR  - https://directory.doabooks.org/handle/20.500.12854/69348
ER  -