Morcos, Faruck

Information Theory in Molecular Evolution: From Models to Structures and Dynamics - Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 - 1 electronic resource (135 p.)

Open Access

This Special Issue collects novel contributions from scientists in the interdisciplinary field of biomolecular evolution. Works listed here use information theoretical concepts as a core but are tightly integrated with the study of molecular processes. Applications include the analysis of phylogenetic signals to elucidate biomolecular structure and function, the study and quantification of structural dynamics and allostery, as well as models of molecular interaction specificity inspired by evolutionary cues.


Creative Commons


English

books978-3-0365-1212-9 9783036512136 9783036512129

10.3390/books978-3-0365-1212-9 doi


Research & information: general
Biology, life sciences

power law Brownian process Kolmogorov complexity entropy chaos monofractal non-linear cumulative sum sequence analysis protein engineering direct coupling analysis evolutionary coupling analysis contact prediction phylogenetic bias phylogeny co-evolution coevolutionary analysis direct-coupling analysis specificity determining contacts sequence reweighting maximum entropy models protein contact predictions TEM-1 TOHO-1 PBP-A DD-transpeptidase conformational changes catalytic mechanism evolution epistasis allostery elastic network model protein conformational dynamics statistical inference mutational phenotypes interaction specificity phosphorylation fitness landscape bacterial signaling n/a