Ciccodicola, Alfredo <br/><br/>
Transcriptional Regulation: Molecules, Involved Mechanisms and Misregulation 

 -  MDPI - Multidisciplinary Digital Publishing Institute  2019 
 - 1 electronic resource (356 p.) 
<br/><br/> Open Access 
<br/><br/> Transcriptional regulation is a critical biological process involved in the response of a cell, a tissue or an organism to a variety of intra- and extra-cellular signals. Besides, it controls the establishment and maintenance of cell identity throughout developmental and differentiation programs. This highly complex and dynamic process is orchestrated by a huge number of molecules and protein networks and occurs through multiple temporal and functional steps. Of note, many human disorders are characterized by misregulation of global transcription since most of the signaling pathways ultimately target components of transcription machinery. This book includes a selection of papers that illustrate recent advances in our understanding of transcriptional regulation and focuses on many important topics, from cis-regulatory elements to transcription factors, chromatin regulators and non-coding RNAs, other than several transcriptome studies and computational analyses. 
<br/><br/><br/>Creative Commons 
<br/><br/><br/>English 
<br/><br/><label>ISBN: </label>books978-3-03921-266-8 9783039212651 9783039212668 
<br/><br/><label>Standard No.: </label>10.3390/books978-3-03921-266-8  doi 
<br/><br/><label>Subjects--Index Terms: </label>transcription factor n/a transcription self-incompatibility cytogenetics epigenetics selenocysteine tea AP-2? nonsense-mediated decay transcriptomics Akt1 promoter cell metabolism pediveliger larvae Patau Syndrome tristetraprolin (TTP) long non-coding RNA (lncRNA) pregnancy G-quadruplex glioblastoma placenta PRDM gene family circRNA-disease associations bioadhesive gene expression Crassostrea gigas transcription regulation cell differentiation RNA interference transcriptome inflammatory response FOXO1 Adiponectin liquid chromatograph-tandem mass spectrometer (LC-MS/MS) selenium selenocysteine insertion sequence inflammation selenoproteins research methods nutritional status structures and functions CRISPR/Cas9 fertilization melanin differentially expressed genes tyrosinase posttranscriptional regulation major depressive disorder human malignancies pathway CDKN1C transcription factors p57Kip2 enhancer activity mouse disorders high-throughput RNA sequencing (RNA-Seq) TCGA data analysis RNA-seq heterogeneous network insect and drug design therapeutic targets mechanisms obesity Pacific oyster Rsh regulon common pathway Pax3 somatic mutations nutrition molecular docking bioinformatics interactome long non-coding RNAs transcriptional regulation Pteria penguin (Röding Adiponectin receptors transcriptome profiling 1798) N-acyl-l-homoserine lactone ppGpp tumorigenesis sphingomonads human disease adenosine and uridine-rich elements (AREs) progress and prospects miR-25-3p acute leukemia Novosphingobium pentaromativorans US6-1 microscopy cancer molecular pathways causal inference