TY  - GEN
AU  - Satarug,Soisungwan
TI  - Cadmium Sources and Toxicity
SN  - books978-3-03897-985-2
PY  - 2019///
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - microRNAs
KW  - n/a
KW  - embryonic kidneys
KW  - exposure assessment
KW  - image analysis
KW  - periodontal disease
KW  - menopause
KW  - nephrotoxicity
KW  - urine protein
KW  - mitochondrial morphology
KW  - female
KW  - alveolar bone
KW  - population health
KW  - glomerular filtration rate
KW  - threshold limit
KW  - biomarkers
KW  - toxicity threshold limit
KW  - osteotoxicity
KW  - intrauterine exposure
KW  - metabolic syndrome
KW  - dietary cadmium
KW  - periodontitis
KW  - cadmium toxicity
KW  - metabolic disruptor
KW  - cadmium
KW  - urine cadmium
KW  - chronic kidney disease
KW  - N-acetyl-?-d-glucosaminidase
KW  - estimated glomerular filtration rate
KW  - one health
KW  - clinical kidney function measure
KW  - ?2-microglobulin
KW  - cause of death
KW  - follow-up study
KW  - menarche
KW  - HIF-1
KW  - bioenergetics
KW  - sub-lethal exposure
KW  - metformin
KW  - toxicological mechanism
KW  - tubular dysfunction
KW  - mitochondrial network
KW  - environmental pollution
KW  - mortality
KW  - body burden indicator
KW  - cancer
KW  - hypertension
N1  - Open Access
N2  - Cadmium (Cd) is an environmental toxicant of continuing public health concern worldwide, because total diet studies have shown that Cd is present in virtually all foodstuffs. Consequently, foods that are frequently consumed in large quantities, such as rice, potatoes, wheat, leafy salad vegetables, and other cereal crops, are the most significant dietary Cd sources. Moreover, Cd has chemical propensities that confer the potential to interfere with the physiological functions of calcium and zinc. Evidence of a wide range of diverse, toxic effects of Cd is increasingly apparent. In this collection, environmental Cd exposure is linked to an increased risk of chronic kidney disease that is known to be a cause of morbidity and mortality worldwide. Cd is also implicated in an early onset of menarche and deaths from cancer, especially in the uterus, kidney, and urinary tract. Moreover, Cd-induced kidney injury is replicated in Sprague Dawley rats, as is Cd-induced periodontal disease. Experimental studies suggest that the development of kidneys in fetuses and the function of insulin-producing cells may be adversely affected by Cd and that metformin, an anti-diabetic drug, is ineffective in Cd-intoxicated Wistar rats
UR  - https://mdpi.com/books/pdfview/book/1336
UR  - https://directory.doabooks.org/handle/20.500.12854/42575
ER  -