Hitzmann, Bernd <br/><br/>
Bioprocess Monitoring and Control 

 - Basel, Switzerland  MDPI - Multidisciplinary Digital Publishing Institute  2020 
 - 1 electronic resource (234 p.) 
<br/><br/> Open Access 
<br/><br/> Process monitoring and control are fundamental to all processes; this holds especially for bioprocesses, due to their complex nature. Usually, bioprocesses deal with living cells, which have their own regulatory systems. It helps to adjust the cell to its environmental condition. This must not be the optimal condition that the cell needs to produce whatever is desired. Therefore, a close monitoring of the cell and its environment is essential to provide optimal conditions for production. Without measurement, no information of the current process state is obtained. In this book, methods and techniques are provided for the monitoring and control of bioprocesses. From new developments for sensors, the application of spectroscopy and modelling approaches, the estimation and observer implementation for ethanol production and the development and scale-up of various bioprocesses and their closed loop control information are presented. The processes discussed here are very diverse. The major applications are cultivation processes, where microorganisms were grown, but also an incubation process of bird’s eggs, as well as an indoor climate control for humans, will be discussed. Altogether, in 12 chapters, nine original research papers and three reviews are presented. 
<br/><br/><br/>Creative Commons 
<br/><br/><br/>English 
<br/><br/><label>ISBN: </label>books978-3-03936-933-1 9783039369324 9783039369331 
<br/><br/><label>Standard No.: </label>10.3390/books978-3-03936-933-1  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Research & information: general<br/>Biology, life sciences
<br/><br/><label>Subjects--Index Terms: </label>bioenvironmental control model-predictive controller zonal controlling dynamic modelling flotation bioleaching frother mixed culture machine learning Raman spectroscopy downstream processing chromatography flow cell extended Kalman filter biotechnological processes bioreactor control specific growth rate control batch-to-batch reproducibility thermal sensation thermal comfort machine-learning prediction adaptive controlling thermal growth curve temperature modeling thermoregulation monitoring and control bioprocess engineering calorimetry biocontrol agent Bacillus subtilis natto isolation molecular identification medium optimization antimicrobial activity bactericides spectral analyses biological selenate reduction electron donor competition nitrate perchlorate sequencing batch Pseudomonas siderophores antagonism batch fermentation exponential fed-batch fermentation bio-friendly formulations biocontrol nonlinear state estimation geometric observer bioreactor continuous system model-based sensor well-defined macromolecules sequence-defined macromolecules sequence-defined polymers conjugated oligomers oligo(arylene ethynylene)s biosensors sensors process monitoring bioprocess monitoring and control signal noise management dielectric spectroscopy PAT microbial bioprocessing n/a