TY  - GEN
AU  - Avato,Pinarosa
TI  - Natural Products and Drug Discovery
SN  - books978-3-03928-747-5
PY  - 2020///
PB  - MDPI - Multidisciplinary Digital Publishing Institute
KW  - dihydrochalcones
KW  - cytotoxicity-guided
KW  - n/a
KW  - harpagoside
KW  - biotechnology
KW  - synergy
KW  - Imperata cylindrica
KW  - 5?-dimethylchalcone (DMC)
KW  - antioxidant activity
KW  - marine resources
KW  - phenolic derivatives
KW  - secondary metabolites
KW  - antimicrobial agents
KW  - antimicrobial resistance
KW  - metabolomics
KW  - Humulus lupulus
KW  - chromatography
KW  - stereochemistry
KW  - FSE
KW  - cytokines
KW  - cytotoxic activity
KW  - glutamate
KW  - angiogenesis
KW  - traditional medicine
KW  - Ca2+
KW  - L6 cell
KW  - human colon cancer cell lines
KW  - siphonous green algae
KW  - anti-inflammatory activity
KW  - Phyllanthus chamacristoides
KW  - spectroscopic analysis
KW  - Physcomitrella patens
KW  - Leishmania mexicana mexicana
KW  - dementia
KW  - prenylated phenolic compounds
KW  - T2DM
KW  - HPLC-ESI-microTOF-Q-MS/MS
KW  - Eruca sativa
KW  - Dryopteris fragrans
KW  - chemosystematics
KW  - 2?
KW  - cerebellum
KW  - Cleistocalyx operculatus
KW  - inflammation
KW  - multivariate data analysis
KW  - Phyllanthus orbicularis
KW  - HPLC
KW  - cardiovascular disease
KW  - Kv7 potassium channels
KW  - marine peptides
KW  - proliferation
KW  - sulfated coumarins
KW  - Orobanche s.l
KW  - phenylpropanoid glycosides
KW  - Harpagophytum procumbens
KW  - sesquiterpenoids
KW  - TRPV1
KW  - Fideloside
KW  - phenylethanoid glycosides
KW  - Cuba
KW  - molecular network
KW  - NMR
KW  - ketamine
KW  - aging
KW  - GLUT4
KW  - diabetes
KW  - oxidative stress
KW  - Lamiales
KW  - circular dichroism
KW  - psychosis
KW  - antinociceptive
KW  - immuno-regulation activity
KW  - terpenoids
KW  - NADPH oxidases
KW  - diabetic neuropathy
KW  - spagyric tincture
KW  - H2S
KW  - celastrol
KW  - isolation and quantification
KW  - 4?-dihydroxy-6?-methoxy-3?
KW  - Leea indica
KW  - C-glycoside
KW  - neuropathic pain
KW  - PANC-1
KW  - glucosinolates
KW  - flavonoids
KW  - bioactivities of natural products
KW  - cardamonin
KW  - isoflavones
KW  - terpenes
KW  - methicillin-resistant Staphylococcus aureus
KW  - malaria
KW  - artemisinin
KW  - natural products
KW  - devil’s claw
KW  - ACE inhibitory peptide
KW  - pPancreatic cancer
KW  - growth inhibitory activity
KW  - mass spectrometry
KW  - flavonoid
KW  - phenolics
KW  - Astragalus boeticus L
KW  - proanthocyanidins
KW  - opioid
KW  - Trifolium
KW  - Trypanosoma brucei brucei
KW  - acetylated astragalosides
KW  - Fabaceae
KW  - bioactive peptides
KW  - LC-MS
KW  - Dasycladus vermicularis
KW  - Orobanchaceae
KW  - migration
KW  - glucoerucin
KW  - ESI-MS/MS
KW  - cancer
KW  - zebrafish
KW  - antihypertensive
KW  - Bacopa monnieri
KW  - chemical derivatization
KW  - hypertension
N1  - Open Access
N2  - Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays
UR  - https://mdpi.com/books/pdfview/book/2231
UR  - https://directory.doabooks.org/handle/20.500.12854/54359
ER  -