Ferraris, Davide Maria <br/><br/>
<em>Mycobacterium tuberculosis</em> Pathogenesis, Infection Prevention and Treatment 

 - Basel, Switzerland  MDPI - Multidisciplinary Digital Publishing Institute  2020 
 - 1 electronic resource (128 p.) 
<br/><br/> Open Access 
<br/><br/> Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB) and it represents a persistent public health threat for a number of complex biological and sociological reasons. According to the most recent Global Tuberculosis Report (2019) edited by the World Health Organization (WHO), TB is considered the ninth cause of death worldwide and the leading cause of mortality by a single infectious agent, with the highest rate of infections and death toll rate mostly concentrated in developing and low-income countries. We present here the editorial section to the Special Issue entitled “Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment” that includes 7 research articles and a review. The scientific contributions included in the Special Issue mainly focus on the characterization of MTB strains emerging in TB endemic countries as well as on multiple mechanisms adopted by the bacteria to resist and to adapt to antitubercular therapies. 
<br/><br/><br/>Creative Commons 
<br/><br/><br/>English 
<br/><br/><label>ISBN: </label>books978-3-03936-659-0 9783039366583 9783039366590 
<br/><br/><label>Standard No.: </label>10.3390/books978-3-03936-659-0  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Research & information: general<br/>Biology, life sciences
<br/><br/><label>Subjects--Index Terms: </label>Mycobacterium tuberculosis line probe assay second-line drugs drug resistance XDR-TB MDR-TB omics analysis TB treatment system analysis Beijing B0/W148 Mycobacterium smegmatis imidazo[1,2-b][1,2,4,5]tetrazine MmpS5-MmpL5 efflux drug discovery tuberculosis immune activation HLA-DR CD38 treatment response Mycobacterium macrophage apoptosis effector cytokine microRNA Beijing genotype Central Asia Outbreak murine infection model Virulence pre-XDR-TB Mycobacterium avium unique metabolic pathways subtractive genomics drug target uncharacterized proteins BM-MSCs Mtb bone-homing stem cell niche latent tuberculosis relapse liposomes M. tuberculosis host-pathogen interactions immune response antitubercular drug discovery antitubercular treatments IL-18 IL-18BP IL-18R gene expression