Awasthi, Amit <br/><br/>
T Cell Differentiation and Function in Tissue Inflammation 

 -  Frontiers Media SA  2020 
 - 1 electronic resource (231 p.) 
<br/><br/> Open Access 
<br/><br/> Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors. 
<br/><br/><br/>Creative Commons 
<br/><br/><br/>English 
<br/><br/><label>ISBN: </label>978-2-88963-614-3 9782889636143 
<br/><br/><label>Standard No.: </label>10.3389/978-2-88963-614-3  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Medicine<br/>Immunology
<br/><br/><label>Subjects--Index Terms: </label>CD4 T cell CD8 T cell Cancer autoimmune disease Inflammation