TY - GEN AU - Awasthi,Amit AU - Goswami,Ritobrata AU - Awasthi,Amit AU - Goswami,Ritobrata TI - T Cell Differentiation and Function in Tissue Inflammation SN - 978-2-88963-614-3 PY - 2020/// PB - Frontiers Media SA KW - Medicine KW - bicssc KW - Immunology KW - CD4 T cell KW - CD8 T cell KW - Cancer KW - autoimmune disease KW - Inflammation N1 - Open Access N2 - Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors UR - https://www.frontiersin.org/research-topics/6209/t-cell-differentiation-and-function-in-tissue-inflammation UR - https://directory.doabooks.org/handle/20.500.12854/73756 ER -