TY - GEN AU - Gozzelino,Raffaella AU - Poli,Maura AU - Arosio,Paolo TI - Iron as Therapeutic Targets in Human Diseases Volume 1 SN - books978-3-03928-083-4 PY - 2020/// PB - MDPI - Multidisciplinary Digital Publishing Institute KW - developmental KW - Anemia of chronic disease KW - neurodegeneration KW - supplementation KW - MHC KW - iron chelation therapy KW - osteoblast KW - serum biomarker KW - FeSO4 KW - haptoglobin KW - prevention KW - brain development KW - pituitary KW - trauma KW - hepcidin KW - Alzheimer’s disease KW - chaotropes KW - social behavior KW - Africa KW - macrophage KW - anemia of inflammation KW - Tfr2 KW - chelation KW - cardiomyocyte KW - IV iron therapy KW - Oxidative stress KW - treatment KW - chronic kidney disease KW - iron homeostasis KW - oxygen sensing KW - iron chelators KW - age-related macular degeneration (AMD) KW - pharmaceutical targets KW - non-transferrin-bound iron (NTBI) KW - iron dextran KW - pulmonary arterial hypertension KW - labile iron KW - low and middle income countries KW - ferroportin KW - gut microbiota KW - reducibility KW - non-HFE KW - oxidative stress KW - antitumor compound KW - senescence KW - electron transfer KW - nanotechnology KW - iron deficiency KW - neonatal period KW - heme oxygenase KW - hypoxia KW - Anemia KW - NCOA4 KW - patient blood management KW - microbiome KW - anemia KW - iron mobilization KW - iron release KW - phlebotomy KW - peritoneal dialysis KW - Friedreich Ataxia KW - ferritin KW - CD8+ T cells KW - M cells KW - neurodegenerative disease KW - NaFeEDTA KW - vascular calcification KW - cinnamic acid derivatives KW - oral iron salts KW - lipid KW - acute lung injury KW - Iron-sulfur KW - Interleukin-6 KW - neurodegeneration with brain iron accumulation KW - macrophages KW - erythroblastic islands KW - cystic fibrosis KW - neuroimmune responses KW - flavin nucleotide KW - hemopexin KW - Iron chelators KW - nutrient iron KW - developing countries KW - hereditary hypoferritinemia KW - iron KW - cancer KW - Indonesia KW - n/a KW - Hfe KW - HFE KW - chronic heart failure KW - iron supplementation KW - intestinal inflammation KW - TNF KW - chelators KW - hemolysis KW - children KW - pulmonary arterial smooth muscle cells KW - cytokines KW - didox KW - intravenous iron KW - T lymphocytes KW - colorectal cancer KW - infants KW - liver KW - ferritinophagy KW - hereditary hyperferritinemia KW - SCFA KW - rheumatoid arthritis KW - membrane interactions KW - Sucrosomial® iron KW - lung KW - Kupffer cell KW - iron chelation KW - erythrophagocytosis KW - acute kidney injury KW - neurophysiology KW - iron transporters KW - iron absorption KW - infection KW - ferroptosis KW - fluorescent iron chelator KW - neonatal KW - SNC KW - immunity KW - mycobacteria KW - non-haem iron KW - natural history KW - 3-hydroxy-4-pyridinone KW - haem KW - inflammation KW - bone homeostasis KW - cardiovascular disease KW - heme KW - heme homeostasis KW - protein binding KW - brain KW - iron deficiency anemia KW - Fe2+-chelating activity KW - bioengineering KW - Mek/Erk KW - Bmp/Smad KW - iron delivery KW - genetic hemochromatosis KW - osteoclast KW - histidine KW - rhodamine KW - COPD KW - hemorrhage KW - antibacterial activity KW - bacteria KW - SLC40A1 KW - transferrin receptor KW - drug delivery KW - nanocage KW - soybean seed ferritin KW - pig KW - iron metabolism KW - kidney KW - innate immunity KW - cataracts syndrome KW - erythropoiesis KW - obesity KW - mucosal immunity KW - iron overload KW - fluorophore KW - binding ability KW - inflammatory bowel disease (IBD) KW - osteoporosis KW - biomarker KW - bioavailability KW - adverse event profile KW - metabolism KW - iron-carbohydrate complex KW - kinetics KW - flavonoids KW - iron regulatory proteins KW - lung infection KW - non transferrin bound iron KW - central nurse macrophage KW - iron processing KW - malaria KW - neurodegenerative diseases KW - multifunctional iron chelators KW - retina KW - neuroinflammation KW - anti-hepcidin therapy KW - lung diseases KW - anaemia KW - RRM2 KW - cognition KW - mitochondria KW - therapy KW - NBIA KW - red pulp macrophage KW - efficacy KW - hemochromatosis KW - tolerability KW - oral iron therapy KW - growth KW - venesections N1 - Open Access N2 - Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions UR - https://mdpi.com/books/pdfview/book/2016 UR - https://directory.doabooks.org/handle/20.500.12854/50679 ER -