Aggregatibacter actinomycetemcomitans—Gram-Negative Bacterial Pathogen
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ArticleLanguage: English Publication details: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021Description: 1 electronic resource (232 p.)ISBN: - books978-3-03943-377-3
- 9783039433766
- 9783039433773
- Research & information: general
- Biology, life sciences
- Aggregatibacter actinomycetemcomitans
- cagE
- virB1
- virB4
- genotype
- virulence
- mRNA assay
- quantitative ELISA
- cell lysis assay
- leukotoxin
- JP2 genotype
- cytolethal distending toxin
- lipopolysaccharides
- cytokine binding factors
- horizontal gene transfer
- outer membrane vesicles
- biofilm
- proteomic
- adherence
- endocarditis
- fimbriae
- JP2
- periodontitis
- taxonomy
- core and accessory genes
- average nucleotide identity
- principal component analysis
- keratins
- organotypic gingival mucosa
- A. actinomycetemcomitans
- RNA-Seq
- genomic islands
- core genes
- accessory genes
- stress
- nutrient limitation
- differentially expressed genes
- lymphocytes
- apoptosis
- RTX toxin
- localized aggressive periodontitis
- LFA-1
- leukotoxin (LtxA)
- endocytosis
- n/a
- JP2 clone of Aggregatibacter actinomycetemcomitans
- JP2 in Caucasian
- microbiological diagnosis
- adjunctive antibiotics
- localized aggressive periodontitis: animal studies: human studies
- landscape ecology
- damage/response framework
- bacteremia
- horseshoe crab
- Origanum vulgare
- essential oil
- antimicrobial activity
- minimum inhibitory concentration
- minimal bactericidal concentration
- cytotoxicity
- leukotoxin neutralization
- inflammasome
- immune response
- periodontal disease
- proteomics
Open Access star Unrestricted online access
Aggregatibacter actinomycetemcomitans is a well-studied Gram-negative bacterium that can often be found in the oral cavity of young individuals. It has several virulence factors and a large genetic diversity, which results in both harmless and highly virulent genotypes. To determine the virulence potential of the isolated bacteria, genetic profiling is recommended. Advanced knowledge of the virulence mechanisms induced by this bacterium is important for the development of future personalized preventive and treatment strategies. The fifteen papers in this book provide a strong and relevant background that can contribute to the improvement of future diagnosis and research strategies.
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