Mitogen Activated Protein Kinases : Functions in Signal Transduction and Human Diseases
Material type:
ArticleLanguage: English Publication details: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020Description: 1 electronic resource (276 p.)ISBN: - books978-3-03928-071-1
- 9783039280704
- 9783039280711
- Research & information: general
- Biology, life sciences
- Rabdosia inflexa
- inflammation
- gastric ulcer
- cytokines
- MAPK
- NF-κB
- extracellular signal-regulated kinases 1/2
- hyperoxia
- bronchopulmonary dysplasia
- HPAECs
- angiogenesis
- cell cycle
- SIRT1
- oxidative stress
- psoriasis
- antimicrobial peptide
- cecropin A
- tight junction protein
- MEK/ERK signaling
- porcine intestinal epithelial cell
- extracellular signal-regulated kinase 5 (ERK5)
- Kv4.2
- PC12 cells
- infantile myofibromatosis
- receptor tyrosine kinases
- platelet-derived growth factor receptor
- protein kinase inhibitors
- sunitinib
- erlotinib
- FR180204
- U0126
- targeted therapy
- apoptosis
- ERK1/2
- JNKs
- mitochondrial dysfunction
- neurodegeneration
- neuro-inflammation
- p38 MAPKs
- Parkinson’s disease
- mitogen-activated protein kinases (MAPKs)
- MAPK kinetics
- osteoclast differentiation
- bone remodeling
- DAPK
- ERK
- p38
- JNK
- mitogen-activated protein kinase pathway (MAPK pathway)
- protein tyrosine phosphatase interacting protein 51 (PTPIP51)
- protein-protein interaction (PPI)
- cancer signaling
- SR
- CR
- Compatibility
- T2DM
- metabolic profiling
- MAPK/PI3K/Akt signaling pathway
- reactive oxygen species
- PTPN6
- SRC
- DOK4
- MKK4
- MKK7
- p53
- DUSP1
- SIRT2
- atherosclerosis
- aortic valve sclerosis
- aortic valve stenosis
- naphthalimide-metal complex conjugates
- N-heterocyclic carbene
- mitochondria
- ROS
- p38 MAPK
- cancer
- FGF-induced signaling
- FRS2
- phosphorylation
- downregulation
- n/a
Open Access star Unrestricted online access
Mitogen-activated protein kinases (MAPK) are a large family of enzymes that function as signal transducers to regulate a diverse range of physiological responses. However, signaling via extracellular signal-regulated kinase (ERK), c-Jun amino terminal kinase (JNK), and p38 MAPK also underpin many disease processes. This Special Issue provides new insights into how MAPK signaling contributes to specific pathological processes across a range of conditions, including disorders of lung development, type 2 diabetes, proliferative skin diseases, cardiovascular diseases, and neurological diseases.
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