| 000 | 02861naaaa2200265uu 4500 | ||
|---|---|---|---|
| 001 | https://directory.doabooks.org/handle/20.500.12854/70272 | ||
| 020 | _aintechopen.71433 | ||
| 024 | 7 |
_a10.5772/intechopen.71433 _cdoi |
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| 041 | 0 | _aEnglish | |
| 042 | _adc | ||
| 072 | 7 |
_aMJD _2bicssc |
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| 100 | 1 |
_aGero, Domokos _4auth |
|
| 245 | 1 | 0 | _aChapter Hyperglycemia-Induced Endothelial Dysfunction |
| 260 |
_bInTechOpen _c2018 |
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| 506 | 0 |
_aOpen Access _2star _fUnrestricted online access |
|
| 520 | _aGlucose-induced endothelial dysfunction plays a fundamental role in the development of diabetic vascular complications and glycemic control (the foundation of diabetes care) provides limited protection against the cardiovascular complications. Therefore, identification of novel drug targets and treatment approaches for diabetes complications represent a key direction of current pharmaceutical research. The “unifying theory” of hyperglycemia-induced endothelial cell injury organizes the events of cellular dysfunction in a linear cascade and identifies mitochondrial superoxide generation as the triggering event of the injury. Exposure to high glucose concentration for long periods or repeated glycemic swings may induce changes in metabolic substrate availability and lead to mitochondrial hyperpolarization. Changes in the mitochondrial membrane potential induce superoxide production by the electron transport chain and result in oxidative stress. Mitochondrial superoxide is also responsible for the induction of other sources of reactive oxygen species (ROS) within the cells, including advanced glycation end products (AGEs) and the NADPH oxidase. Mitochondria also show morphological changes and impaired assembly of the respiratory complexes occurs, which results in cellular energy failure, cell senescence and vascular dysfunction. Current intervention strategies aim to inhibit the mitochondrial ROS production and novel therapeutic approaches are expected to provide valuable tools in diabetes therapy in the upcoming years. | ||
| 540 |
_aCreative Commons _fhttps://creativecommons.org/licenses/by/3.0/ _2cc _4https://creativecommons.org/licenses/by/3.0/ |
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| 546 | _aEnglish | ||
| 650 | 7 |
_aCardiovascular medicine _2bicssc |
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| 653 | _ahyperglycemia, diabetes, endothelial cells, oxidative stress, mitochondria, electron transport chain, superoxide, bioenergetics | ||
| 773 | 1 | 0 |
_0OAPEN Library ID: ONIX_20210602_10.5772/intechopen.71433_371 _7nnaa |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://library.oapen.org/bitstream/20.500.12657/49257/1/57915.pdf _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://library.oapen.org/bitstream/20.500.12657/49257/1/57915.pdf _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/70272 _70 _zDOAB: description of the publication |
| 999 |
_c38113 _d38113 |
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