000 02920naaaa2200349uu 4500
001 https://directory.doabooks.org/handle/20.500.12854/70187
020 _aintechopen.85690
024 7 _a10.5772/intechopen.85690
_cdoi
041 0 _aEnglish
042 _adc
072 7 _aMMFM
_2bicssc
100 1 _aSarnatskaya, V. V.
_4auth
700 1 _aSnezhkova, E. A.
_4auth
700 1 _aChekhun, Vasyl F.
_4auth
700 1 _aVg, Nikolaev
_4auth
700 1 _aBilous, Anatoliy G.
_4auth
700 1 _aShevchuk, O. O.
_4auth
700 1 _aBadakhivska, Kvitoslava I.
_4auth
700 1 _aSakhno, L. A.
_4auth
245 1 0 _aChapter Sorption Detoxification as an Addition to Conventional Therapy of Acute Radiation Sickness and Iatrogenic Leukopenia
260 _bInTechOpen
_c2019
506 0 _aOpen Access
_2star
_fUnrestricted online access
520 _aLeukopenia is an essential part of the clinical course of acute radiation sickness and is a side effect of anti-cancer treatment. In both situations, the main factors which determine the survival are the degree of bone marrow suppression and gastrointestinal tract damage due to the presence of a large pool of fast-dividing cells. Leuko- and neutropenia are main limiting factors which may contribute to chemotherapy failure. Hematopoietic cytokines the part of conventional therapy in this field, but their effects require boosting. That is why the use of means and methods of adsorption therapy is considered promising. Sorption therapy creates a basis for sorption detoxification, a doctrine of curative measures directed to the removal of toxic endogenous or exogenous compounds from body fluids. The most widely used types are the purification of blood or its components (hemosorption), oral administration of sorption materials (enterosorption) and application-sorption therapy of wounds and burns. In this chapter, the results of early and recent research and prospects for the use of carbon adsorption therapy for the treatment of acute radiation sickness and cytostatic myelosuppression are discussed.
540 _aCreative Commons
_fhttps://creativecommons.org/licenses/by/3.0/
_2cc
_4https://creativecommons.org/licenses/by/3.0/
546 _aEnglish
650 7 _aMedical microbiology & virology
_2bicssc
653 _aleukopenia, ionizing irradiation, anti-cancer chemotherapy, granulocyte colony stimulating factor, hemosorption, enterosorption, application-sorption therapy
773 1 0 _0OAPEN Library ID: ONIX_20210602_10.5772/intechopen.85690_426
_7nnaa
856 4 0 _awww.oapen.org
_uhttps://library.oapen.org/bitstream/20.500.12657/49312/1/66927.pdf
_70
_zDOAB: download the publication
856 4 0 _awww.oapen.org
_uhttps://library.oapen.org/bitstream/20.500.12657/49312/1/66927.pdf
_70
_zDOAB: download the publication
856 4 0 _awww.oapen.org
_uhttps://directory.doabooks.org/handle/20.500.12854/70187
_70
_zDOAB: description of the publication
999 _c38183
_d38183