000			04332naaaa2200325uu 4500
001			https://directory.doabooks.org/handle/20.500.12854/53141
005			20220219202120.0
020			_a978-2-88945-487-7
020			_a9782889454877
024	7		_a10.3389/978-2-88945-487-7 _cdoi
041	0		_aEnglish
042			_adc
100	1		_aVincent David _4auth
700	1		_aDaniel Beracochea _4auth
700	1		_aMark E. Walton _4auth
245	1	0	_aMemory Systems of the Addicted Brain: The Underestimated Role of Drug-Induced Cognitive Biases in Addiction and Its Treatment
260			_bFrontiers Media SA _c2018
300			_a1 electronic resource (163 p.)
506	0		_aOpen Access _2star _fUnrestricted online access
520			_aDrug addiction may be viewed as a form of learning during which strong associations linking actions to drug-seeking are expressed as persistent stimulus–response habits, thereby maintaining a vulnerability to relapse. Disrupting cue–drug memory could be an efficient strategy to reduce the strength of cues in motivating drug-taking behavior. Upon reactivation, these memories undergo a reconsolidation process that can be blocked pharmacologically, providing an opportunity to prevent the powerful control of drug cues on behavior. This conceptually elegant approach still calls for more experimental data. However, an increasing body of evidence suggests that drug taking not only accelerates habit forming, but has long-lasting effects on interactions between memory systems eventually leading to a functional imbalance. The dorsal part of the striatum plays a critical role in habit/procedural learning, whereas the hippocampal memory system encodes relationships between events and their later flexible use. Both humans and rodents studies support the view that the hippocampus and the dorsal striatum interact in either a cooperative or competitive manner during learning, the prefrontal cortex being involved in the selection of an appropriate learning strategy. Chronic drug consumption biases normal interactions between these memory systems. For instance, drug-experienced rodents tend to use preferentially striatum-dependent learning strategies in navigational tasks. These persistent effects seem to occur at cellular, neurophysiological and behavioral levels to promote specific, striatal-dependent forms of learning, to the detriment of spatial/declarative, hippocampal-dependent and more flexible types of memory. Whether cue sensitive and response learners, in contrast to spatial learners, could be prone to drug addiction is an intriguing hypothesis which clearly deserves to be further explored. A loss of flexibility may be uncovered also by imposing changing rules on the subject, such as requiring an attentional shift between different perceptual features of a complex stimulus, as in the attentional set shifting task which was recently adapted to rodents. Working memory is at risk during transition phases, although it remains to be determined whether withdrawal-induced alterations are observed also during protracted abstinence. Drug-induced cognitive biases thus lead to cognitive rigidity which could play a critical, yet overlooked role in different phases of addiction (acquisition, extinction/withdrawal and relapse). They are also likely to preclude the clinical efficiency of treatments. Therefore, the aim of this research topic is to provide an overview of the current work investigating the long-term impact of drug use on learning and memory processes, how multiple memory systems modulate drug-seeking behavior, as well as how drug-induced cognitive biases could contribute to the persistence of addictive behaviors.
540			_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/
546			_aEnglish
653			_aalcohol
653			_amemory systems
653			_adecision-making
653			_aaddiction
653			_ahabit learning
856	4	0	_awww.oapen.org _uhttps://www.frontiersin.org/research-topics/3795/memory-systems-of-the-addicted-brain-the-underestimated-role-of-drug-induced-cognitive-biases-in-add _70 _zDOAB: download the publication
856	4	0	_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/53141 _70 _zDOAB: description of the publication
999			_c41445 _d41445