000 08432naaaa2202665uu 4500
001 https://directory.doabooks.org/handle/20.500.12854/69315
005 20220219202307.0
020 _abooks978-3-03943-301-8
020 _a9783039433001
020 _a9783039433018
024 7 _a10.3390/books978-3-03943-301-8
_cdoi
041 0 _aEnglish
042 _adc
072 7 _aM
_2bicssc
100 1 _aFromm, Michael
_4edt
700 1 _aKrug, Susanne M.
_4edt
700 1 _aFromm, Michael
_4oth
700 1 _aKrug, Susanne M.
_4oth
245 1 0 _aThe Tight Junction and Its Proteins : More Than Just a Barrier
260 _aBasel, Switzerland
_bMDPI - Multidisciplinary Digital Publishing Institute
_c2020
300 _a1 electronic resource (432 p.)
506 0 _aOpen Access
_2star
_fUnrestricted online access
520 _aFor a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
540 _aCreative Commons
_fhttps://creativecommons.org/licenses/by/4.0/
_2cc
_4https://creativecommons.org/licenses/by/4.0/
546 _aEnglish
650 7 _aMedicine
_2bicssc
653 _atissue barrier
653 _atight junction
653 _aclaudins
653 _atricellulin
653 _atight junctions
653 _aorgan preservation
653 _aintestine
653 _atransplantation
653 _aischemia
653 _aintestinal mucosa
653 _alung
653 _aepithelia
653 _ainterleukin 13
653 _aUBE2Z
653 _aubiquitin
653 _aosmolality
653 _ahydrostatic pressure
653 _acancer
653 _asensor
653 _atricellular tight junctions
653 _aendometrial cancer
653 _aepithelial barrier dysfunction
653 _aClaudin-7
653 _apermeability
653 _aWNK4
653 _aepithelial sodium channel (ENaC), collecting duct cells
653 _aclaudin-1
653 _ahydrogen peroxide
653 _aphosphorylation
653 _aclaudin
653 _aangulin
653 _adrug development
653 _aangubindin-1
653 _aClostridium perfringens enterotoxin
653 _aClostridium perfringens iota-toxin
653 _aantibody
653 _aMz-ChA-1 cells
653 _abiliary epithelial cells
653 _aphosphatidylcholine
653 _amucus
653 _aparacellular transport
653 _aatopic dermatitis
653 _acytokines
653 _aSTAT3
653 _aZO-2
653 _acholestasis
653 _agene transcription
653 _ahypertrophy
653 _atumor suppressor
653 _aNLS
653 _aNES
653 _aCaSR
653 _aRhoA
653 _abarrier function
653 _aparacellular permeability
653 _aantidiuretic hormone
653 _aClaudin-14
653 _aCLDN14
653 _ahearing loss
653 _avestibular function
653 _acochlear implantation
653 _aHepatitis C Virus
653 _aviral entry
653 _aepidermal barrier
653 _areconstructed human epidermis
653 _aclaudin targeting
653 _aCampylobacter jejuni
653 _acurcumin
653 _aapoptosis
653 _aco-culture
653 _amouse colon
653 _aTNF
653 _aNFκB
653 _alipolysis-stimulated lipoprotein receptor (LSR)
653 _aepithelial barrier
653 _acell–cell contact
653 _acaspase
653 _akidney stones
653 _aion reabsorption
653 _aquercetin
653 _abrain barriers
653 _ablood-brain barrier
653 _aneurovascular unit
653 _ablood-cerebrospinal fluid barrier
653 _aarachnoid barrier
653 _aglia limitans
653 _aadherens junctions
653 _aparacellular sodium transport
653 _athick ascending limb
653 _anephropathy
653 _aHELIX syndrome
653 _ahypokalemia
653 _ahypermagnesemia
653 _aanhidrosis
653 _agland dysfunction
653 _aaging
653 _ablood–brain barrier
653 _amutations
653 _akidney
653 _aliver
653 _askin
653 _ahuman
653 _amice
653 _adisease
653 _ain silico
653 _adrug discovery
653 _amembrane proteins
653 _aprotein interactions
653 _amolecular dynamics
653 _aantibiotic-associated hemorrhagic colitis
653 _aKlebsiella oxytoca
653 _atight junction assembly
653 _amonocytes
653 _aceliac disease
653 _aclaudin-2
653 _aepithelium
653 _ainflammation
653 _afibrosis
653 _aproliferation
653 _amigration
653 _atricellular tight junction
653 _aparacellular water transport
653 _atight epithelium
653 _aMDCK C7 cells
653 _acell growth
653 _aendothelia
653 _aadherens junction
653 _aapical junctional complex
653 _aAMP-activated protein kinase (AMPK)
653 _aparacellular barrier
653 _aprotein structure
653 _aprotein domain
653 _aoccludin
653 _ajunctional adhesion molecule
653 _azonula occludens
653 _aMAGUK proteins
653 _aPDZ domain
653 _astem cell
653 _achemoresistance
653 _aretinal pigment epithelium
653 _aretinopathy
653 _abarrier formation
653 _acollecting duct
653 _aclaudin-5
653 _aneuropathic pain
653 _anerve injury
653 _adorsal root ganglion
653 _aenteropathogenic E. coli (EPEC)
653 _atight junctions (TJ)
653 _apolarity
653 _aatypical aPKCζ
653 _atransepithelial electrical resistance (TER)
653 _asorting nexin 9 (SNX9)
653 _aEspF
653 _aclaudin 1
653 _atumor
653 _ametastasis
653 _aepithelial to mesenchymal transition
653 _acerebral cavernous malformation
653 _aendothelial barrier
653 _aRho
653 _aROCK
653 _aMEKK3
653 _aion transport
653 _aion channel
653 _asuper-resolution microscopy
653 _astructured illumination microscopy
653 _astimulated emission depletion
653 _asingle molecule localization microscopy
653 _aClaudin
653 _ablood-biliary barrier
653 _achronic liver disease
653 _ahepatocellular carcinoma
653 _acholangiocellular carcinoma
653 _aNISCH syndrome
653 _arepair
653 _aNHE2
653 _aClC-2
653 _ainflammatory bowel disease
653 _amucosal immunology
653 _aZO-1
653 _aactomyosin
653 _aaquaporin
653 _adrinking rate
653 _aepithelial fluid transport
653 _aenterocyte
653 _aosmoregulation
653 _aparacellular
653 _aproximal tubule
653 _acalcium permeability
653 _aclaudin-12
653 _aparacellular channels and barriers
653 _acell polarity
653 _apathogens
653 _aimmune cells
653 _aenvironmental sensors
856 4 0 _awww.oapen.org
_uhttps://mdpi.com/books/pdfview/book/3107
_70
_zDOAB: download the publication
856 4 0 _awww.oapen.org
_uhttps://directory.doabooks.org/handle/20.500.12854/69315
_70
_zDOAB: description of the publication
999 _c41546
_d41546