000			02140naaaa2200385uu 4500
001			https://directory.doabooks.org/handle/20.500.12854/55788
005			20220219203321.0
020			_a978-2-88919-684-5
020			_a9782889196845
024	7		_a10.3389/978-2-88919-684-5 _cdoi
041	0		_aEnglish
042			_adc
100	1		_aPaolo Bonaldo _4auth
700	1		_aLuciano Merlini _4auth
700	1		_aEmanuele Marzetti _4auth
245	1	0	_aPathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
260			_bFrontiers Media SA _c2015
300			_a1 electronic resource (248 p.)
506	0		_aOpen Access _2star _fUnrestricted online access
520			_aLoss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.
540			_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/
546			_aEnglish
653			_aAging sarcopenia
653			_amuscular dystrophy
653			_aMitochondrial dysfunction
653			_atherapy
653			_askeletal muscle
653			_aAutophagy
653			_aAnimal Models
653			_aApoptosis
653			_asatellite cells
653			_amuscle imaging
856	4	0	_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/2299/pathophysiological-mechanisms-of-sarcopenia-in-aging-and-in-muscular-dystrophy-a-translational-appro _70 _zDOAB: download the publication
856	4	0	_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/55788 _70 _zDOAB: description of the publication
999			_c42066 _d42066