| 000 | 02842naaaa2200325uu 4500 | ||
|---|---|---|---|
| 001 | https://directory.doabooks.org/handle/20.500.12854/70493 | ||
| 020 | _aintechopen.75737 | ||
| 024 | 7 |
_a10.5772/intechopen.75737 _cdoi |
|
| 041 | 0 | _aEnglish | |
| 042 | _adc | ||
| 072 | 7 |
_aMB _2bicssc |
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| 100 | 1 |
_aHolzgang, Melanie _4auth |
|
| 700 | 1 |
_aEigl, Benjamin _4auth |
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| 700 | 1 |
_aErdem, Suna _4auth |
|
| 700 | 1 |
_aGloor, Beat _4auth |
|
| 700 | 1 |
_aWorni, Mathias _4auth |
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| 245 | 1 | 0 | _aChapter Irreversible electroporation in pancreatic cancer |
| 260 |
_bInTechOpen _c2018 |
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| 506 | 0 |
_aOpen Access _2star _fUnrestricted online access |
|
| 520 | _aPancreatic cancer is the deadliest of the gastrointestinal tract with 5-year survival rates of less than 5%. Given common asymptomatic early disease course, most patients (50%) present with an already metastatic disease, while only 20% can undergo potentially curative resection. The remaining 30% present with locally advanced disease, defined as extended vascular encasement, where the risk of surgical therapy often outweighs its benefits. Traditional thermal local ablative modalities (RFA, MWA, or cryotherapy) have the disadvantage that they are not applicable in proximity to vital vascular structures, which are abundant in the peripancreatic region. Irreversible electroporation (IRE) is an emerging non-thermal alternative that induces apoptosis of tumor cells by the delivery of short repetitive impulses of high-voltage electric current. Given its mostly non-thermal modality, IRE is not hampered by a heat-sink effect and is applicable with little risk around vascular structures, bile and pancreatic ducts. Recent research suggests that local tumor destruction through IRE improves overall survival, progression-free survival and quality of life in patients with locally advanced pancreatic cancer. | ||
| 540 |
_aCreative Commons _fhttps://creativecommons.org/licenses/by/3.0/ _2cc _4https://creativecommons.org/licenses/by/3.0/ |
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| 546 | _aEnglish | ||
| 650 | 7 |
_aMedicine: general issues _2bicssc |
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| 653 | _alocally advanced pancreatic cancer, borderline resectable pancreatic cancer, irreversible electroporation, local tumor destruction, apoptosis, overall survival | ||
| 773 | 1 | 0 |
_0OAPEN Library ID: ONIX_20210602_10.5772/intechopen.75737_373 _7nnaa |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://library.oapen.org/bitstream/20.500.12657/49259/1/60217.pdf _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://library.oapen.org/bitstream/20.500.12657/49259/1/60217.pdf _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://library.oapen.org/bitstream/20.500.12657/49259/1/60217.pdf _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/70493 _70 _zDOAB: description of the publication |
| 999 |
_c43584 _d43584 |
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