000			04103naaaa2200853uu 4500
001			https://directory.doabooks.org/handle/20.500.12854/53437
005			20220219215705.0
020			_abooks978-3-03921-715-1
020			_a9783039217151
020			_a9783039217144
024	7		_a10.3390/books978-3-03921-715-1 _cdoi
041	0		_aEnglish
042			_adc
100	1		_aSubramanian, Subree _4auth
700	1		_aSteer, Clifford _4auth
245	1	0	_amicroRNA Regulation in Health and Disease
260			_bMDPI - Multidisciplinary Digital Publishing Institute _c2020
300			_a1 electronic resource (154 p.)
506	0		_aOpen Access _2star _fUnrestricted online access
520			_aMicroRNAs (miRNAs) are small regulatory RNAs that play a crucial role in posttranscriptional gene regulation. Over two thousand miRNAs have been identified in humans, and many of them are conserved in other species. miRNAs are implicated in fundamental cellular functions, including development and disease. In the last decade, there has been an overwhelming amount of data contributing to the understanding of miRNA biogenesis and their target genes. Moreover, a significant amount of work has been carried out in developing miRNA biomarkers and therapeutics for various disease conditions. RNA-based markers and therapeutics have been proven to have a clinical impact, and many of these miRNA-based therapies are at various stages of human clinical trials and clinical applications. Notably, miRNAs are also found in exosomes, and are considered to impart intercellular communication and function via several different modalities, including tunneling nanotubes. In spite of our understanding of miRNA biology and function, there are many challenges in effectively using miRNAs as biomarkers and therapeutic agents in clinical applications. In this Special Issue, we are inviting reviews, perspectives, and original research articles to address some of these challenges. Topics will include, but are not limited to, miRNA biogenesis, clinical applications, extracellular function, biomarkers, miRNA immune regulation, signaling pathways, and preclinical models.
540			_aCreative Commons _fhttps://creativecommons.org/licenses/by-nc-nd/4.0/ _2cc _4https://creativecommons.org/licenses/by-nc-nd/4.0/
546			_aEnglish
653			_amicroRNAs
653			_an/a
653			_alipoprotein
653			_amyofibroblast
653			_amiR-148a
653			_aC2C12 cell line
653			_aendometrial receptivity
653			_ainterstitial lung disease
653			_aexon switch
653			_aatherosclerosis
653			_acolorectal cancer
653			_alet-7
653			_amiR-125b
653			_aidiopathic pulmonary fibrosis
653			_abiomarker
653			_arecurrent implantation failure
653			_asevere acute respiratory syndrome coronavirus
653			_amiRSNP
653			_atransfer
653			_amiR-106a-5p
653			_asomatostatin analogues
653			_aneuroendocrine tumors
653			_agene expression
653			_auremia
653			_aHKII
653			_amiRNAs
653			_ametabolic interactions
653			_anon-Hodgkin lymphoma
653			_aPIK3R1
653			_asmall RNA
653			_amiR-7
653			_aHexokinase 2
653			_aCD34 cryptic splicing
653			_asystemic sclerosis
653			_asmall RNA-seq
653			_amyogenic differentiation
653			_aproteomics
653			_aCD34 cell-clusters
653			_apalindromic small RNA
653			_ainfertility
653			_agut microbiota
653			_aORF miRNA target
653			_aDNA complemented palindrome
653			_ars17723799
653			_acomplemented palindromic small RNA
653			_aMIR143
653			_amicroRNA
653			_acancer
653			_amuscle atrophy
856	4	0	_awww.oapen.org _uhttps://mdpi.com/books/pdfview/book/2044 _70 _zDOAB: download the publication
856	4	0	_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/53437 _70 _zDOAB: description of the publication
999			_c46383 _d46383