000			04213naaaa2200373uu 4500
001			https://directory.doabooks.org/handle/20.500.12854/44468
005			20220219220217.0
020			_a978-2-88919-858-0
020			_a9782889198580
024	7		_a10.3389/978-2-88919-858-0 _cdoi
041	0		_aEnglish
042			_adc
100	1		_aJurgen Bernhagen _4auth
700	1		_aHeidi Noels _4auth
245	1	0	_aThe CXCR4 Ligand/Receptor Family and the DPP4 Protease in High-Risk Cardiovascular Patients
260			_bFrontiers Media SA _c2016
300			_a1 electronic resource (163 p.)
506	0		_aOpen Access _2star _fUnrestricted online access
520			_aCardiovascular disease (CVD) is the most common cause of morbidity and mortality worldwide, putting a major burden on life quality and social health care systems. Type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) have been identified as important risk factors for CVD, severely increasing the risk on e.g. myocardial infarction, and cardiovascular complications constitute the main cause of death in patients presenting with T2DM, CKD or a combination of both. As these pathologies are expected to rise alarmingly in the next decades, a better understanding of molecular and cellular mechanisms contributing to T2DM, CKD and CVD is required to improve prevention and treatment of these diseases. Furthermore, insight into the interplay between these pathologies and identification of molecular players interconnecting these comorbidities is of tremendous importance for optimal health management in the future. This Research Topic will focus on the chemokine receptor CXCR4 and its ligands CXCL12/SDF-1a and macrophage migration inhibitory factor (MIF) in the context of CVD and its link with T2DM and CKD, as well as address dipeptidyl peptidase-4 (DPP4) as an important protease destabilizing CXCL12. Chemokines and their receptors are important mediators of cell mobilization, recruitment and arrest, and also more broadly induce cell activation by triggering various intracellular signalling tracks. They control homeostatic conditions, but are also critically involved in inflammatory and pathological processes. Genome-wide association studies revealed single nucleotide polymorphisms connecting CXCL12 as well as MIF with CVD, and a role for both chemokines in T2DM and CKD has also been reported. In this review collection, current knowledge on molecular aspects of the CXCR4 ligand/receptor family and associated signalling pathways will be discussed. The physiological roles of CXCR4, CXCL12, MIF and DPP4 will be summarized, and recent findings on their function in pathological conditions of CVD, T2DM and CKD will be highlighted. This is combined with an extensive introduction providing insight into the pathologies of CVD, T2DM and CKD, discussing clinical features and common pathological aspects of these comorbidities on cellular and molecular level. Also, an overview of available animal models to study these diseases will be provided. This way, this Research Topic summarizes latest knowledge on this crucial molecular axis and its relationship with cardiovascular pathologies for both specialists and interested non-specialists and aims to stimulate further initiatives to unravel the mechanistic involvement of the CXCR4 ligand/receptor family in these morbidities, potentially paving the way for new therapeutical initiatives in the future.
540			_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/
546			_aEnglish
653			_acardiovascular disease
653			_achemokine
653			_aCXCL12/SDF-1
653			_adipeptidyl peptidase
653			_aCXCR4
653			_akidney disease
653			_aMIF
653			_aDPP4/CD26
653			_adiabetes
653			_achemokine receptor
856	4	0	_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/3372/the-cxcr4-ligandreceptor-family-and-the-dpp4-protease-in-high-risk-cardiovascular-patients _70 _zDOAB: download the publication
856	4	0	_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/44468 _70 _zDOAB: description of the publication
999			_c46660 _d46660