| 000 | 02294naaaa2200373uu 4500 | ||
|---|---|---|---|
| 001 | https://directory.doabooks.org/handle/20.500.12854/48746 | ||
| 005 | 20220219222028.0 | ||
| 020 | _a978-2-88919-757-6 | ||
| 020 | _a9782889197576 | ||
| 024 | 7 |
_a10.3389/978-2-88919-757-6 _cdoi |
|
| 041 | 0 | _aEnglish | |
| 042 | _adc | ||
| 100 | 1 |
_aCatherine Rabouille _4auth |
|
| 700 | 1 |
_aGeorg Haase _4auth |
|
| 245 | 1 | 0 | _aGolgi Pathology in Neurodegenerative Diseases |
| 260 |
_bFrontiers Media SA _c2016 |
||
| 300 | _a1 electronic resource (119 p.) | ||
| 506 | 0 |
_aOpen Access _2star _fUnrestricted online access |
|
| 520 | _aThe Golgi apparatus is a central organelle that lies at the heart of the secretory pathway. It ensures post-translational protein modifications such as glycosylation and cleavage as well as protein sorting to neuronal axons and dendrites. Structural and functional alterations of the Golgi apparatus (fragmentation and atrophy), which are collectively termed Golgi pathology, are now recognized as a constant feature of many neuro-degenerative diseases. However, the molecular mechanisms underlying these changes and their precise relevance to neurodegeneration have not yet been completely elucidated. This eBook contains 13 reviews that address the molecular mechanisms of Golgi pathology in Parkinson and Alzheimer diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophies, and discuss their potential relevance to the pathological loss of neuronal cell bodies, axons and synapses. | ||
| 540 |
_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/ |
||
| 546 | _aEnglish | ||
| 653 | _aNeurodegenerative Diseases | ||
| 653 | _aIntracellular membrane traffic | ||
| 653 | _aAmyotrophic Lateral Sclerosis | ||
| 653 | _asignaling | ||
| 653 | _aGolgi fragmentation | ||
| 653 | _aMicrotubules | ||
| 653 | _aCell Death | ||
| 653 | _aTethers | ||
| 653 | _amolecular motors | ||
| 653 | _avesicles | ||
| 856 | 4 | 0 |
_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/3815/golgi-pathology-in-neurodegenerative-diseases _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/48746 _70 _zDOAB: description of the publication |
| 999 |
_c47574 _d47574 |
||