| 000 | 02784naaaa2200337uu 4500 | ||
|---|---|---|---|
| 001 | https://directory.doabooks.org/handle/20.500.12854/67245 | ||
| 005 | 20220220025236.0 | ||
| 020 | _aintechopen.71387 | ||
| 020 | _a9781789844931 | ||
| 020 | _a9781789844924 | ||
| 020 | _a9781789849820 | ||
| 024 | 7 |
_a10.5772/intechopen.71387 _cdoi |
|
| 041 | 0 | _aEnglish | |
| 042 | _adc | ||
| 072 | 7 |
_aMFN _2bicssc |
|
| 100 | 1 |
_aLogie, Colin _4edt |
|
| 700 | 1 |
_aAurelius Knoch, Tobias _4edt |
|
| 700 | 1 |
_aLogie, Colin _4oth |
|
| 700 | 1 |
_aAurelius Knoch, Tobias _4oth |
|
| 245 | 1 | 0 | _aChromatin and Epigenetics |
| 260 |
_bIntechOpen _c2020 |
||
| 300 | _a1 electronic resource (294 p.) | ||
| 506 | 0 |
_aOpen Access _2star _fUnrestricted online access |
|
| 520 | _aGenomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The public awareness culminated in the much anticipated race to decipher the sequence of the human genome in 2002. Over all those years, it has become apparent that genomic DNA is compacted into chromatin with a dedicated 3D higher-order organization and dynamics, and that on each structural level epigenetic modifications exist. The book "Chromatin and Epigenetics" addresses current issues in the fields of epigenetics and chromatin ranging from more theoretical overviews in the first four chapters to much more detailed methodologies and insights into diagnostics and treatments in the following chapters. The chapters illustrate in their depth and breadth that genetic information is stored on all structural and dynamical levels within the nucleus with corresponding modifications of functional relevance. Thus, only an integrative systems approach allows to understand, treat, and manipulate the holistic interplay of genotype and phenotype creating functional genomes. The book chapters therefore contribute to this general perspective, not only opening opportunities for a true universal view on genetic information but also being key for a general understanding of genomes, their function, as well as life and evolution in general. | ||
| 540 |
_aCreative Commons _fhttps://creativecommons.org/licenses/by/3.0/ _2cc _4https://creativecommons.org/licenses/by/3.0/ |
||
| 546 | _aEnglish | ||
| 650 | 7 |
_aMedical genetics _2bicssc |
|
| 653 | _aMedical genetics | ||
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://mts.intechopen.com/storage/books/6582/authors_book/authors_book.pdf _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/67245 _70 _zDOAB: description of the publication |
| 999 |
_c60626 _d60626 |
||