000			02056naaaa2200325uu 4500
001			https://directory.doabooks.org/handle/20.500.12854/54593
005			20220220031625.0
020			_aintechopen.78254
020			_a9781839622045
020			_a9781839622069
020			_a9781839622052
024	7		_a10.5772/intechopen.78254 _cdoi
041	0		_aEnglish
042			_adc
100	1		_aMichal Tomcik _4auth
245	1	0	_aNew Insights into Systemic Sclerosis
260			_bIntechOpen _c2019
300			_a1 electronic resource (160 p.)
506	0		_aOpen Access _2star _fUnrestricted online access
520			_aSystemic sclerosis (scleroderma) is an incurable connective tissue disease of unknown etiology. Three key processes play a pivotal role in the pathogenesis: immune dysregulation and inflammation, endothelial injury and vasculopathy, and fibrosis. Tissue fibrosis is the dominant and characteristic feature that affects the skin and visceral organs. Life expectancy of scleroderma patients has improved over recent years, mainly because of better treatment of organ involvement and complications; however, no curative disease-modifying therapies exist to date. This book aims to provide students, trainees, rheumatologists, and other specialists interested in this disease with a comprehensive overview of novel pathogenetic mechanisms, management approaches, and therapeutic targets of several major vascular and fibrotic manifestations, and is useful insight into a number of usually neglected aspects of scleroderma.
540			_aAll rights reserved _4http://oapen.org/content/about-rights
546			_aEnglish
653			_aMedicine
653			_aImmunopathology
653			_aImmunology
653			_aAllergology and Rheumatology
653			_aHealth Sciences
856	4	0	_awww.oapen.org _uhttps://www.intechopen.com/books/new-insights-into-systemic-sclerosis _70 _zDOAB: download the publication
856	4	0	_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/54593 _70 _zDOAB: description of the publication
999			_c61773 _d61773