| 000 | 03255naaaa2200373uu 4500 | ||
|---|---|---|---|
| 001 | https://directory.doabooks.org/handle/20.500.12854/53402 | ||
| 005 | 20220220032050.0 | ||
| 020 | _a978-2-88919-280-9 | ||
| 020 | _a9782889192809 | ||
| 024 | 7 |
_a10.3389/978-2-88919-280-9 _cdoi |
|
| 041 | 0 | _aEnglish | |
| 042 | _adc | ||
| 100 | 1 |
_aAmal O. Amer _4auth |
|
| 700 | 1 |
_aYongqun He _4auth |
|
| 245 | 1 | 0 | _aMicrobial Modulation of Host Apoptosis and Pyroptosis |
| 260 |
_bFrontiers Media SA _c2014 |
||
| 300 | _a1 electronic resource (109 p.) | ||
| 506 | 0 |
_aOpen Access _2star _fUnrestricted online access |
|
| 520 | _aInfectious disease is the result of an interactive relationship between a microbial pathogen and its host. In this interaction both the host and the pathogen attempt to manipulate each other using a complex network to maximize their respective survival probabilities. Programmed host cell death is a direct outcome of host-pathogen interaction and may benefit host or pathogen depending on microbial pathogenesis. Apoptosis and pyroptosis are two common programmed cell death types induced by various microbial infections. Apoptosis is non-inflammatory programmed cell death and can be triggered through intrinsic or extrinsic pathways and with or without the contribution of mitochondria. Pyroptosis is an inflammatory cell death and is typically triggered by caspase-1 after its activation by various inflammasomes. However, some non-canonical caspase-1-independent proinflammatory cell death phenomena have been reported. Microbial pathogens are able to modulate host apoptosis and pyroptosis through different triggers and pathways. The promotion and inhibition of host apoptosis and pyroptosis vary and depend on the microbe types, virulence, and phenotypes. For example, virulent pathogens and attenuated vaccine strains may use different pathways to modulate host cell death. Specific microbial genes may be responsible for the modulation of host cell death. Different host cells, including macrophages, dendritic cells, and T cells, can undergo apoptosis and pyroptosis after microbial infections. The pathways of host apoptosis and pyroptosis induced by different microbes may also differ. Different methods can be used to study the interaction between microbes and host cell death system. The articles included in this E-book report the cutting edge findings in the areas of microbial modulation of host apoptosis, pyroptosis and inflammasome. | ||
| 540 |
_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/ |
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| 546 | _aEnglish | ||
| 653 | _amicrobial infection | ||
| 653 | _apyroptosis | ||
| 653 | _aMycobacterium tuberculosis | ||
| 653 | _abacterial exploitation of apoptosis | ||
| 653 | _aBrucella | ||
| 653 | _aInfectious Disease | ||
| 653 | _aInflammasome | ||
| 653 | _aLegionella | ||
| 653 | _aprogrammed cell death | ||
| 653 | _aApoptosis | ||
| 856 | 4 | 0 |
_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/1309/microbial-modulation-of-host-apoptosis-and-pyroptosis _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/53402 _70 _zDOAB: description of the publication |
| 999 |
_c61999 _d61999 |
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