000			02188naaaa2200337uu 4500
001			https://directory.doabooks.org/handle/20.500.12854/46667
005			20220220040509.0
020			_a978-2-88919-458-2
020			_a9782889194582
024	7		_a10.3389/978-2-88919-458-2 _cdoi
041	0		_aEnglish
042			_adc
100	1		_aTania L. Roth _4auth
700	1		_aKarestan C. Koenen _4auth
700	1		_aDavid M. Diamond _4auth
245	1	0	_aEpigenetic pathways in PTSD: How traumatic experiences leave their signature on the genome
260			_bFrontiers Media SA _c2015
300			_a1 electronic resource (158 p.)
506	0		_aOpen Access _2star _fUnrestricted online access
520			_aThis research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry.
540			_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/
546			_aEnglish
653			_aPTSD
653			_astress
653			_aFear
653			_aDNA Methylation
653			_aHistones
653			_amiRNA
856	4	0	_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/966/epigenetic-pathways-in-ptsd-how-traumatic-experiences-leave-their-signature-on-the-genome _70 _zDOAB: download the publication
856	4	0	_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/46667 _70 _zDOAB: description of the publication
999			_c64064 _d64064