| 000 | 03910naaaa2200733uu 4500 | ||
|---|---|---|---|
| 001 | https://directory.doabooks.org/handle/20.500.12854/48392 | ||
| 005 | 20220220044935.0 | ||
| 020 | _abooks978-3-03921-679-6 | ||
| 020 | _a9783039216796 | ||
| 020 | _a9783039216789 | ||
| 024 | 7 |
_a10.3390/books978-3-03921-679-6 _cdoi |
|
| 041 | 0 | _aEnglish | |
| 042 | _adc | ||
| 100 | 1 |
_aRose, Giuseppina _4auth |
|
| 700 | 1 |
_aSørensen, Mette _4auth |
|
| 700 | 1 |
_aDato, Serena _4auth |
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| 245 | 1 | 0 | _aGenetic Determinants of Human Longevity |
| 260 |
_bMDPI - Multidisciplinary Digital Publishing Institute _c2019 |
||
| 300 | _a1 electronic resource (118 p.) | ||
| 506 | 0 |
_aOpen Access _2star _fUnrestricted online access |
|
| 520 | _aIn the last two decades, due to the continuous increase of lifespans in Westernsocieties, and the consequent growing of the elderly population, have witnessedan increase in the number of studies on biological and molecular factors able topromote healthy aging and reach longevity. The study of the genetic componentof human longevity demonstrated that it accounts for 25% of intra populationphenotype variance. The efforts made to characterize the genetic determinantssuggested that the maintenance of cellular integrity, inflammation, oxidativestress response, DNA repair, as well as the use of nutrients, represent the mostimportant pathways correlated with a longer lifespan. However, although aplethora of variants were indicated to be associated with human longevity, onlyvery few were successfully replicated in different populations, probably becauseof population specificity, missing heritability as well as a complex interactionamong genetic factors with lifestyle and cultural factors, which modulate theindividual chance of living longer. Thus, many challenges remain to be addressedin the search for the genetic components of human longevity. This Special Issue isaimed to unify the progress in the analysis of the genetic determinants of humanlongevity, to take stock of the situation and point to future directions of the field.We invite submissions for reviews, research articles, short-communicationsdealing with genetic association studies in human longevity, including all types ofgenetic variation, as well as the characterization of longevity-related genes. | ||
| 540 |
_aCreative Commons _fhttps://creativecommons.org/licenses/by-nc-nd/4.0/ _2cc _4https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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| 546 | _aEnglish | ||
| 653 | _aunknown zygosity | ||
| 653 | _aexceptional longevity | ||
| 653 | _aTERC | ||
| 653 | _axenobiotic-metabolizing enzymes | ||
| 653 | _alifespan | ||
| 653 | _agender-specific association | ||
| 653 | _along-livers | ||
| 653 | _apolymorphism | ||
| 653 | _acumulative incidence curves | ||
| 653 | _acardiovascular health | ||
| 653 | _atwins | ||
| 653 | _agenetic determinants of human longevity | ||
| 653 | _aTERT | ||
| 653 | _aSNP | ||
| 653 | _amoonlighting protein | ||
| 653 | _alongevity | ||
| 653 | _agenomics | ||
| 653 | _aAPOE | ||
| 653 | _apolygenic risk score | ||
| 653 | _asignal transduction | ||
| 653 | _axenobiotics | ||
| 653 | _asurvival | ||
| 653 | _aIPMK | ||
| 653 | _agenetic variation | ||
| 653 | _agenetic association study | ||
| 653 | _amolecular senescence | ||
| 653 | _azygosity | ||
| 653 | _alongevity-related genes | ||
| 653 | _aage-stratification | ||
| 653 | _alipid profile | ||
| 653 | _amortality | ||
| 653 | _aapolipoprotein E | ||
| 653 | _aaging | ||
| 653 | _amodel systems | ||
| 653 | _aleukocyte telomere length | ||
| 653 | _ainositol phosphates | ||
| 653 | _ahuman lifespan | ||
| 653 | _apopulations | ||
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://mdpi.com/books/pdfview/book/1752 _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/48392 _70 _zDOAB: description of the publication |
| 999 |
_c66089 _d66089 |
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