000 02210naaaa2200301uu 4500
001 https://directory.doabooks.org/handle/20.500.12854/65329
005 20220220055541.0
020 _a1064
020 _a9789533077253
020 _a9789535151753
024 7 _a10.5772/1064
_cdoi
041 0 _aEnglish
042 _adc
072 7 _aPSG
_2bicssc
100 1 _aChatterjee, Pradeep
_4edt
700 1 _aChatterjee, Pradeep
_4oth
245 1 0 _aBacterial Artificial Chromosomes
260 _bIntechOpen
_c2011
300 _a1 electronic resource (150 p.)
506 0 _aOpen Access
_2star
_fUnrestricted online access
520 _aThis book focuses on the numerous applications of Bacterial Artificial Chromosomes (BACs) in a variety of studies. The topics reviewed range from using BAC libraries as resources for marsupial and monotreme gene mapping and comparative genomic studies, to using BACs as vehicles for maintaining the large infectious DNA genomes of viruses. The large size of the insert DNA in BACs and the ease of engineering mutations in that DNA within the bacterial host, allowed manipulating the BAC-viral DNA of Varicella-Zoster Virus. Other reviews include the maintenance and suitable expression of foreign genes from a Baculovirus genome, including protein complexes, from the BAC-viral DNA and generating vaccines from BAC-viral DNA genomes of Marek's disease virus. Production of multi-purpose BAC clones in the novel Bacillus subtilis host is described, along with chapters that illustrate the use of BAC transgenic animals to address important issues of gene regulation in vertebrates, such as functionally identifying novel cis-acting distal gene regulatory sequences.
540 _aCreative Commons
_fhttps://creativecommons.org/licenses/by/3.0/
_2cc
_4https://creativecommons.org/licenses/by/3.0/
546 _aEnglish
650 7 _aMicrobiology (non-medical)
_2bicssc
653 _aBacteriology (non-medical)
856 4 0 _awww.oapen.org
_uhttps://mts.intechopen.com/storage/books/554/authors_book/authors_book.pdf
_70
_zDOAB: download the publication
856 4 0 _awww.oapen.org
_uhttps://directory.doabooks.org/handle/20.500.12854/65329
_70
_zDOAB: description of the publication
999 _c69162
_d69162