000			03325naaaa2200373uu 4500
001			https://directory.doabooks.org/handle/20.500.12854/53258
005			20220220062250.0
020			_a978-2-88919-739-2
020			_a9782889197392
024	7		_a10.3389/978-2-88919-739-2 _cdoi
041	0		_aEnglish
042			_adc
100	1		_aKatja M. Kanninen _4auth
700	1		_aAnthony R. White _4auth
700	1		_aPeter J. Crouch _4auth
245	1	0	_aMetals and neurodegeneration: Restoring the balance
260			_bFrontiers Media SA _c2016
300			_a1 electronic resource (132 p.)
506	0		_aOpen Access _2star _fUnrestricted online access
520			_aBiometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s, Parkinson’s, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative disorders. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging. These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. These approaches range from genetic manipulation of biometal transport to chelation of excess metals or delivery of metals where levels are deficient. A number of these approaches are offering promising results in cellular and animal models of neurodegeneration with successful translation to pre-clinical and clinical trials. At a time of aging populations and slow progress in development of neurotherapeutics to treat age-related neurodegenerative diseases, there is now a critical need to further our understanding of biometals in neurodegeneration. This issue covers a broad range of topics related to biometals and their role in neurodegeneration. It is hoped that this will inspire greater discussion and exchange of ideas in this crucial area of research and lead to positive outcomes for sufferers of these neurodegenerative diseases.
540			_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/
546			_aEnglish
653			_aBrain
653			_aneurodegenerative disease
653			_aNeurons
653			_aMetals
653			_aIron
653			_aCopper
653			_aAlzheimer's disease
653			_aZinc
653			_aManganese
856	4	0	_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/820/metals-and-neurodegeneration-restoring-the-balance _70 _zDOAB: download the publication
856	4	0	_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/53258 _70 _zDOAB: description of the publication
999			_c70353 _d70353