| 000 | 02959naaaa2200337uu 4500 | ||
|---|---|---|---|
| 001 | https://directory.doabooks.org/handle/20.500.12854/53983 | ||
| 005 | 20220220073027.0 | ||
| 020 | _a978-2-88919-389-9 | ||
| 020 | _a9782889193899 | ||
| 024 | 7 |
_a10.3389/978-2-88919-389-9 _cdoi |
|
| 041 | 0 | _aEnglish | |
| 042 | _adc | ||
| 100 | 1 |
_aTakehsi Kaneko _4auth |
|
| 700 | 1 |
_aGordon M. G Shepherd _4auth |
|
| 700 | 1 |
_aMichael Brecht _4auth |
|
| 700 | 1 |
_aNicholas Hatsopoulos _4auth |
|
| 245 | 1 | 0 | _aMotor Cortex Microcircuits (Frontiers in Brain Microcircuits Series) |
| 260 |
_bFrontiers Media SA _c2015 |
||
| 300 | _a1 electronic resource (133 p.) | ||
| 506 | 0 |
_aOpen Access _2star _fUnrestricted online access |
|
| 520 | _aHow does the motor cortex enable mammals to generate accurate, complex, and purposeful movements? A cubic millimeter of motor cortex contains roughly ~10^5 cells, an amazing ~4 Km of axons and ~0.4 Km of dendrites, somehow wired together with ~10^9 synapses. Corticospinal neurons (a.k.a. Betz cells, upper motor neurons) are a key cell type, monosynaptically conveying the output of the cortical circuit to the spinal cord circuits and lower motor neurons. But corticospinal neurons are greatly outnumbered by all the other kinds of neurons in motor cortex, which presumably also contribute crucially to the computational operations carried out for planning, executing, and guiding actions. Determining the wiring patterns, the dynamics of signaling, and how these relate to movement at the level of specific excitatory and inhibitory cell types is critically important for a mechanistic understanding of the input-output organization of motor cortex. While there is a predictive microcircuit hypothesis that relates motor learning to the operation of the cerebellar cortex, we lack such a microcircuit understanding in motor cortex and we consider microcircuits as a central research topic in the field. This Research Topic covers any issues relating to the microcircuit-level analysis of motor cortex. Contributions are welcomed from neuroscientists at all levels of investigation, from in vivo physiology and imaging in humans and monkeys, to rodent models, in vitro anatomy, electrophysiology, electroanatomy, cellular imaging, molecular biology, disease models, computational modeling, and more. | ||
| 540 |
_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/ |
||
| 546 | _aEnglish | ||
| 653 | _aMotor Cortex | ||
| 653 | _aintracortical connectivity | ||
| 653 | _acorticospinal neurons | ||
| 653 | _adirectional tuning | ||
| 653 | _amotor control | ||
| 856 | 4 | 0 |
_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/738/motor-cortex-microcircuits-frontiers-in-brain-microcircuits-series _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/53983 _70 _zDOAB: description of the publication |
| 999 |
_c73404 _d73404 |
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