| 000 | 02594naaaa2200337uu 4500 | ||
|---|---|---|---|
| 001 | https://directory.doabooks.org/handle/20.500.12854/57918 | ||
| 005 | 20220220080619.0 | ||
| 020 | _a978-2-88945-196-8 | ||
| 020 | _a9782889451968 | ||
| 024 | 7 |
_a10.3389/978-2-88945-196-8 _cdoi |
|
| 041 | 0 | _aEnglish | |
| 042 | _adc | ||
| 100 | 1 |
_aBrian McDonagh _4auth |
|
| 245 | 1 | 0 | _aRedox Regulation in Skeletal Muscle Aging and Exercise |
| 260 |
_bFrontiers Media SA _c2017 |
||
| 300 | _a1 electronic resource (101 p.) | ||
| 506 | 0 |
_aOpen Access _2star _fUnrestricted online access |
|
| 520 | _aSkeletal muscle represents the largest organ of the human body and comprises about 40% of total body mass in humans. Even in people who ‘age well’, there is a noticeable loss of muscle strength and function that accelerates dramatically after the age of 60, a major factor in the reduction in life quality for the aging population. One of the most effective interventions to maintain muscle mass and function is through exercise. Skeletal muscle generates reactive oxygen and reactive nitrogen (ROS/RNS) species in response to muscle contractions. The concentration and species of ROS/RNS generated can depend on the age and fitness of the individual, muscle fibre type and the intensity of the muscle contractions. ROS/RNS generate unique signaling cascades that are not only essential in skeletal muscle contraction and adaptation but also play a role in a wide array of cell processes including cell proliferation, protein synthesis/degradation, immune response and antioxidant defense. ROS/RNS generated by contractions are involved in a co-ordinated local response that is tightly controlled at all levels from generation to detoxification. This collection of original articles and reviews highlights investigations that measure different aspects of the redox response of skeletal muscle to aging and exercise. | ||
| 540 |
_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/ |
||
| 546 | _aEnglish | ||
| 653 | _aMitochondria | ||
| 653 | _aSternohyoid muscle | ||
| 653 | _auremic myopathy | ||
| 653 | _asphingomyelinase | ||
| 653 | _aMuscle Fatigue | ||
| 653 | _asirt3 | ||
| 653 | _aCalveolin-3 | ||
| 653 | _aNADPH Oxidase | ||
| 856 | 4 | 0 |
_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/2723/redox-regulation-in-skeletal-muscle-aging-and-exercise _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/57918 _70 _zDOAB: description of the publication |
| 999 |
_c74992 _d74992 |
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