| 000 | 03534naaaa2200385uu 4500 | ||
|---|---|---|---|
| 001 | https://directory.doabooks.org/handle/20.500.12854/57915 | ||
| 005 | 20220220083149.0 | ||
| 020 | _a978-2-88945-635-2 | ||
| 020 | _a9782889456352 | ||
| 024 | 7 |
_a10.3389/978-2-88945-635-2 _cdoi |
|
| 041 | 0 | _aEnglish | |
| 042 | _adc | ||
| 100 | 1 |
_aSalvatore Rizza _4auth |
|
| 700 | 1 |
_aGiuseppe Filomeni _4auth |
|
| 700 | 1 |
_aAndrea Rasola _4auth |
|
| 700 | 1 |
_aDanyelle M. Townsend _4auth |
|
| 245 | 1 | 0 | _aRedox and Metabolic Circuits in Cancer |
| 260 |
_bFrontiers Media SA _c2018 |
||
| 300 | _a1 electronic resource (183 p.) | ||
| 506 | 0 |
_aOpen Access _2star _fUnrestricted online access |
|
| 520 | _aLiving cells require a constant supply of energy for the orchestration of a variety of biological processes in fluctuating environmental conditions. In heterotrophic organisms, energy mainly derives from the oxidation of carbohydrates and lipids, whose chemical bonds breakdown allows electrons to generate ATP and to provide reducing equivalents needed to restore the antioxidant systems and prevent from damage induced by reactive oxygen and nitric oxide (NO)-derived species (ROS and RNS). Studies of the last two decades have highlighted that cancer cells reprogram the metabolic circuitries in order to sustain their high growth rate, invade other tissues, and escape death. Therefore, this broad metabolic reorganization is mandatory for neoplastic growth, allowing the generation of adequate amounts of ATP and metabolites, as well as the optimization of redox homeostasis in the changeable environmental conditions of the tumor mass. Among these, ROS, as well as NO and RNS, which are produced at high extent in the tumor microenvironment or intracellularly, have been demonstrated acting as positive modulators of cell growth and frequently associated with malignant phenotype. Metabolic changes are also emerging as primary drivers of neoplastic onset and growth, and alterations of mitochondrial metabolism and homeostasis are emerging as pivotal in driving tumorigenesis. Targeting the metabolic rewiring, as well as affecting the balance between production and scavenging of ROS and NO-derived species, which underpin cancer growth, opens the possibility of finding selective and effective anti-neoplastic approaches, and new compounds affecting metabolic and/or redox adaptation of cancer cells are emerging as promising chemotherapeutic tools. In this Research Topic we have elaborated on all these aspects and provided our contribution to this increasingly growing field of research with new results, opinions and general overviews about the extraordinary plasticity of cancer cells to change metabolism and redox homeostasis in order to overcome the adverse conditions and sustain their “individualistic” behavior under a teleonomic viewpoint. | ||
| 540 |
_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/ |
||
| 546 | _aEnglish | ||
| 653 | _ahypoxia | ||
| 653 | _aMitochondria | ||
| 653 | _aBioenergetics | ||
| 653 | _aCancer Metabolism | ||
| 653 | _aROS | ||
| 653 | _aS-nitrosylation | ||
| 653 | _aAutophagy | ||
| 653 | _aredox | ||
| 653 | _aWarburg effect | ||
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://www.frontiersin.org/research-topics/6407/redox-and-metabolic-circuits-in-cancer _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/57915 _70 _zDOAB: description of the publication |
| 999 |
_c76132 _d76132 |
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