000			02792naaaa2200313uu 4500
001			https://directory.doabooks.org/handle/20.500.12854/57241
005			20220220085112.0
020			_a978-2-88919-982-2
020			_a9782889199822
024	7		_a10.3389/978-2-88919-982-2 _cdoi
041	0		_aEnglish
042			_adc
100	1		_aMiguel A. Andrade-Navarro _4auth
700	1		_aSpyros Petrakis _4auth
245	1	0	_aProtein Interaction Networks in Health and Disease
260			_bFrontiers Media SA _c2016
300			_a1 electronic resource (89 p.)
506	0		_aOpen Access _2star _fUnrestricted online access
520			_aThe identification and mapping of protein-protein interactions (PPIs) is a major goal in systems biology. Experimental data are currently produced in large scale using a variety of high-throughput assays in yeast or mammalian systems. Analysis of these data using computational tools leads to the construction of large protein interaction networks, which help researchers identify novel protein functions. However, our current view of protein interaction networks is still limited and there is an active field of research trying to further develop this concept to include important processes: the topology of interactions and their changes in real time, the effects of competition for binding to the same protein region, PPI variation due to alternative splicing or post-translational modifications, etc. In particular, a clinically relevant topic for development of the concept of protein interactions networks is the consideration of mutant isoforms, which may be responsible for a pathological condition. Mutations in proteins may result in loss of normal interactions and appearance of novel abnormal interactions that may affect a protein’s function and biological cycle. This Research Topic presents novel findings and recent achievements in the field of protein interaction networks with a focus on disease. Authors describe methods for the identification and quantification of PPIs, the annotation and analysis of networks, considering PPIs and protein complexes formed by mutant proteins associated with pathological conditions or genetic diseases.
540			_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/
546			_aEnglish
653			_aprotein interactions
653			_aDisease
653			_aProtein function
653			_aprotein network
653			_aSystems Biology
856	4	0	_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/3102/protein-interaction-networks-in-health-and-disease _70 _zDOAB: download the publication
856	4	0	_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/57241 _70 _zDOAB: description of the publication
999			_c76987 _d76987