000			04222naaaa2200385uu 4500
001			https://directory.doabooks.org/handle/20.500.12854/56987
005			20220220085318.0
020			_a978-2-88919-767-5
020			_a9782889197675
024	7		_a10.3389/978-2-88919-767-5 _cdoi
041	0		_aEnglish
042			_adc
100	1		_aRudiger J. Seitz _4auth
700	1		_aBruno J. Weder _4auth
700	1		_aRoland Wiest _4auth
245	1	0	_aPrinciples Underlying Post-Stroke Recovery of Upper Extremity Sensorimotor Function - A Neuroimaging Perspective
260			_bFrontiers Media SA _c2016
300			_a1 electronic resource (153 p.)
506	0		_aOpen Access _2star _fUnrestricted online access
520			_aNeuroimaging post-stroke has the potential to uncover underlying principles of disturbed hand function and recovery characterizing defined patient groups, including their long term course as well as individual variations. The methods comprise functional magnetic resonance imaging (MRI) measuring task related activation as well as resting state. Functional MRI may be complemented by arterial spin labeling (ASL) MRI to investigate slowly varying blood flow and associated changes in brain function. For structural MRI robust and accurate computational anatomical methods like voxel-based morphometry and surface based techniques are available. The investigation of the connectivity among brain regions and disruption after stroke is facilitated by diffusion tensor imaging (DTI). Intra- and interhemispheric coherence may be studied by electromagnetic techniques such as electroencephalography and transcranial magnetic stimulation. Consecutive phases of stroke recovery (acute, subacute, early chronic and late chronic stages) are each distinguished by intrinsic processes. The site and size of lesions entail partially different functional implications. New strategies to establish functional specificity of a lesion site include calculating contrast images between patients exhibiting a specific disorder and control subjects without the disorder. Large-size lesions often imply poor cerebral blood flow which impedes recovery significantly and possibly interferes with BOLD response of functional MRI. Thus, depending on the site and size of the infarct lesion the patterns of recovery will vary. These include recovery sensu stricto in the perilesional area, intrinsic compensatory mechanisms using alternative cortical and subcortical pathways, or behavioral compensatory strategies e.g. by using the non-affected limb. In this context, behavioral and neuroimaging measures should be developed and employed to delineate aspects of learning during recovery. Of special interest in recovery of hand paresis is the interplay between sensory and motor areas in the posterior parietal cortex involved during reaching and fine motor skills as well as the interaction with the contralesional hemisphere. The dominant disability should be characterized, from the level of elementary to hierarchically higher processes such as neglect, apraxia and motor planning. In summary, this Research Topic covers new trends in state of the art neuroimaging of stroke during recovery from upper limb paresis. Integration of behavioral and neuroimaging findings in probabilistic brain atlases will further advance knowledge about stroke recovery.
540			_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/
546			_aEnglish
653			_astroke recovery
653			_aMotor Imagery
653			_astructural covariance
653			_aSomatosensory Disorders
653			_aperilesional plasticity
653			_anetwork reorganization
653			_amultimodal neuroimaging
653			_aNeurorehabilitation
653			_acomputational biophysical modeling
653			_amotor control
856	4	0	_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/2914/principles-underlying-post-stroke-recovery-of-upper-extremity-sensorimotor-function---a-neuroimaging _70 _zDOAB: download the publication
856	4	0	_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/56987 _70 _zDOAB: description of the publication
999			_c77084 _d77084