000			03499naaaa2200325uu 4500
001			https://directory.doabooks.org/handle/20.500.12854/57932
005			20220220093141.0
020			_a978-2-88919-808-5
020			_a9782889198085
024	7		_a10.3389/978-2-88919-808-5 _cdoi
041	0		_aEnglish
042			_adc
100	1		_aJessica McDermott Sales _4auth
700	1		_aSteven R.H. Beach _4auth
245	1	0	_aRefining Prevention: Genetic and Epigenetic Contributions
260			_bFrontiers Media SA _c2016
300			_a1 electronic resource (94 p.)
506	0		_aOpen Access _2star _fUnrestricted online access
520			_aCurrently, most prevention efforts are framed as universal interventions. However, despite the demonstrated efficacy of many prevention programs, variability in response is the rule with some participants responding very little and others accounting for the bulk of the positive impact of the program. Better understanding the processes associated with better and worse response to prevention is a critical first step in refining and adapting existing programs, or alternatively designing new prevention programs with enhanced outcomes. Because vulnerabilities to substance use, emotional problems, risky sexual behavior and other behavioral problems are influenced by a combination of environmental, genetic, and epigenetic factors, mediated in part through psychological processes (Kreek et al., 2005; Rutter et al., 2006), the study of genetic and epigenetic vulnerability and susceptibility factors provides an important starting point for efforts to address this critical need. A growing body of research on differential genetic susceptibility indicates that efforts to enhance prevention impact may benefit from consideration of the contribution of individualgenetic differences to treatment response (Brody et al., 2013). In addition, the recent expansion of genetic research to include a focus on epigenetic change provides considerable promise for the development of indicated prevention and individually tailored prevention efforts. However, before this promise can be realized, a number of theoretical and practical challenges remain. Thus, through this special section, we provide a foundation for a new era of prevention research in which the principles of prevention science are combined with genomic science. In the current special section we bring together authors to deal with genetic and epigenetically driven processes relevant to depression, substance abuse, and sexual risk taking. Together they comment on, and provide data relevant to, assessment, research and statistical methods, The papers help to inform the development of a new generation of prevention programs that go beyond universal programs and sensitively target key processes while providing greater precision regarding prediction of population-level impact.
540			_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/
546			_aEnglish
653			_asubstance use
653			_atranslation
653			_aGenetics
653			_aMental Health
653			_aprevention
653			_aepigenetics
856	4	0	_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/3348/refining-prevention-genetic-and-epigenetic-contributions _70 _zDOAB: download the publication
856	4	0	_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/57932 _70 _zDOAB: description of the publication
999			_c78823 _d78823