000			03171naaaa2200313uu 4500
001			https://directory.doabooks.org/handle/20.500.12854/62228
005			20220220093216.0
020			_a978-2-88945-247-7
020			_a9782889452477
024	7		_a10.3389/978-2-88945-247-7 _cdoi
041	0		_aEnglish
042			_adc
100	1		_aErin Joanne Walker _4auth
700	1		_aReena Ghildyal _4auth
245	1	0	_aViral Interactions with the Nucleus
260			_bFrontiers Media SA _c2017
300			_a1 electronic resource (124 p.)
506	0		_aOpen Access _2star _fUnrestricted online access
520			_aViruses cause numerous medically important diseases, affecting developing, developed, rich and poor alike. The diseases vary in severity, including chickenpox, smallpox, influenza, shingles, herpes, rabies, polio, Ebola, hanta fever, AIDS and the common cold, amongst others. Regardless of the type of tissue or organ affected, all viruses follow the same basic steps to infect host cells. Once in contact with host cells viruses release their genetic material into the cell followed by genome replication, production of viral proteins, assembly of the virus particle and egress from the infected cell. Viruses disrupt normal host cell processes in order to facilitate their own replication/assembly by re-directing cellular machinery for viral transcription, translation, assembly, release and by inhibiting antiviral responses. Regulated nuclear transport of macromolecules through the nuclear pore complex, the only means of transport across the nuclear membrane, is essential for normal cell function and an effective antiviral response. Many viruses disrupt or exploit the nucleocytoplasmic trafficking pathways in host cells. Cytoplasmic viruses exploit the host cell nucleocytoplasmic trafficking machinery to access nuclear functions and/or disrupt nuclear transport, while several DNA viruses use the trafficking pathways to enable export of their components into the cytoplasm; yet others complete their assembly within the nucleus and use nuclear export pathways to access the cytoplasm. Indeed, the many and varied interactions of viruses and viral proteins with nucleocytoplasmic trafficking components have been invaluable in pathway discovery. Importantly, mounting evidence suggests that these interactions play essential roles in virus replication/assembly and hence may be key to understanding pathophysiology of viral diseases. This Frontiers Research Topic is dedicated to the importance of nucleocytoplasmic trafficking to viral pathogenesis.
540			_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/
546			_aEnglish
653			_aviral nuclear interactions
653			_anuclear transport
653			_aDNA Viruses
653			_anuclear pore complex
653			_aRNA Viruses
856	4	0	_awww.oapen.org _uhttp://journal.frontiersin.org/researchtopic/2894/viral-interactions-with-the-nucleus _70 _zDOAB: download the publication
856	4	0	_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/62228 _70 _zDOAB: description of the publication
999			_c78847 _d78847