| 000 | 03312naaaa2200409uu 4500 | ||
|---|---|---|---|
| 001 | https://directory.doabooks.org/handle/20.500.12854/73635 | ||
| 005 | 20220220093356.0 | ||
| 020 | _a978-2-88963-481-1 | ||
| 020 | _a9782889634811 | ||
| 024 | 7 |
_a10.3389/978-2-88963-481-1 _cdoi |
|
| 041 | 0 | _aEnglish | |
| 042 | _adc | ||
| 072 | 7 |
_aM _2bicssc |
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| 072 | 7 |
_aMJCM _2bicssc |
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| 100 | 1 |
_aTsuji, Moriya _4edt |
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| 700 | 1 |
_aAkkina, Ramesh _4edt |
|
| 700 | 1 |
_aTsuji, Moriya _4oth |
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| 700 | 1 |
_aAkkina, Ramesh _4oth |
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| 245 | 1 | 0 | _aDevelopment of Humanized Mouse Models for Infectious Diseases and Cancer |
| 260 |
_bFrontiers Media SA _c2020 |
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| 300 | _a1 electronic resource (169 p.) | ||
| 506 | 0 |
_aOpen Access _2star _fUnrestricted online access |
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| 520 | _aWhile the traditional animal models contributed immensely to biomedical research there remain many knowledge gaps in translating the results from these to humans. In this context, humanized mice transplanted with functional human cells in a physiological setting offer many advantages in deriving pre-clinical data more akin to that seen in the natural human host. There have been many recent advances in the field that encompass derivation of new transgenic breeds of immunodeficient mice harboring human cytokines and HLA alleles that permit improved human cell engraftment and differentiation. The ability to generate humanized mice with a functional immune system together with human tissue transplantation such as a functional liver has now paved the way for new experimentation not previously feasible and is beginning to shed light on the complex picture of human pathophysiology and immunopathogenesis. Specifically, human specific pathogens such as HIV, hepatitis viruses and malaria parasites are being studied in these systems and important data on pathogen life cycles in human cells in vivo, viral latency and human specific immune responses are being gathered. In the hematology front, new data are emerging on graft versus host disease using these models. Patient derived xenograft models endowed with transplanted human immune cells are permitting evaluations of various immunotherapies and identification of specific drugs for cancer therapy. Pathogenesis and immune responses for deadly pathogens, such as Ebola and newly emerged viruses like Zika are also being studied, adding a new twist and generating new knowledge in the context of human target cells in an in vivo setting. | ||
| 540 |
_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/ |
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| 546 | _aEnglish | ||
| 650 | 7 |
_aMedicine _2bicssc |
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| 650 | 7 |
_aImmunology _2bicssc |
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| 653 | _ahumanized mice in infectious disease research | ||
| 653 | _ahumanized mice in cancer research | ||
| 653 | _anew humanized mouse models | ||
| 653 | _ahumanized mice for HIV | ||
| 653 | _amalaria | ||
| 653 | _avaccines and therapeutics | ||
| 653 | _aimproved humanized mouse models | ||
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://www.frontiersin.org/research-topics/5454/development-of-humanized-mouse-models-for-infectious-diseases-and-cancer#articles _70 _zDOAB: download the publication |
| 856 | 4 | 0 |
_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/73635 _70 _zDOAB: description of the publication |
| 999 |
_c78919 _d78919 |
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