000			03231naaaa2200349uu 4500
001			https://directory.doabooks.org/handle/20.500.12854/61874
005			20220220102842.0
020			_a978-2-88945-410-5
020			_a9782889454105
024	7		_a10.3389/978-2-88945-410-5 _cdoi
041	0		_aEnglish
042			_adc
100	1		_aFrancisco J. Rivera _4auth
700	1		_aLudwig Aigner _4auth
245	1	0	_aThe Vascular Niche in Tissue Repair: A Therapeutic Target for Regeneration
260			_bFrontiers Media SA _c2018
300			_a1 electronic resource (174 p.)
506	0		_aOpen Access _2star _fUnrestricted online access
520			_aTissues and organs have, although sometimes limited, the capacity for endogenous repair, which is aimed to re-establish integrity and homeostasis. Tissue repair involves pro- and anti-inflammatory processes, new tissue formation and remodelling. Depending on the local microenvironment, tissue repair results either in scar tissue formation or in regeneration. The latter aims to recapitulate the original tissue structure and architecture with the proper functionality. Although some organisms (such as planarians) have a high regenerative capacity throughout the body, in humans this property is more restricted to a few organs and tissues. Regeneration in the adult is possible in particular through the existence of tissue-resident pools of stem/progenitor cells. In response to tissue damage, these cells are activated, they proliferate and migrate, and differentiate into mature cells. Angiogenesis and neovascularization play a crucial role in tissue repair. Besides providing with oxygen and nutrients, angiogenesis generates a vascular niche (VN) consisting of different blood-derived elements and endothelial cells surrounded by basement membrane as well as perivascular cells. The newly generated VN communicates with the local stem/progenitor cells and contributes to tissue repair. For example, platelets, macrophages, neutrophils, perivascular cells and other VN components actively participate in the repair of skin, bone, muscle, tendon, brain, spinal cord, etc. Despite these observations, the exact role of the VN in tissue repair and the underlying mechanisms are still unclear and are awaiting further evidence that, indeed, will be required for the development of regenerative therapies for the treatment of traumatic injuries as well as degenerative diseases.
540			_aCreative Commons _fhttps://creativecommons.org/licenses/by/4.0/ _2cc _4https://creativecommons.org/licenses/by/4.0/
546			_aEnglish
653			_aAngiogenesis
653			_aPlatelets and Platelets Lysate
653			_aBlood Vessels and Endothelial Cells
653			_aGranulocyte Colony Stimulating Factor (G-CSF)
653			_aPericytes
653			_aStem and Progenitor Cells
653			_aVascular Niche
653			_aTissue Repair and Regeneration
856	4	0	_awww.oapen.org _uhttps://www.frontiersin.org/research-topics/3255/the-vascular-niche-in-tissue-repair-a-therapeutic-target-for-regeneration _70 _zDOAB: download the publication
856	4	0	_awww.oapen.org _uhttps://directory.doabooks.org/handle/20.500.12854/61874 _70 _zDOAB: description of the publication
999			_c81338 _d81338